Natural product-like libraries based on non-aromatic, polycyclic motifs

Diversity-oriented synthesis is an intriguing approach for creating structurally diverse compounds that cover the pharmaceutically relevant chemical space in an optimal way. On the other hand, an over-proportionally large number of drugs or lead structures originate from compounds isolated from natu...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in chemical biology 2005-06, Vol.9 (3), p.259-265
Main Authors: Messer, Roland, Fuhrer, Cyril A, Häner, Robert
Format: Article
Language:English
Subjects:
Biological Factors - chemistry
Combinatorial Chemistry Techniques
Databases, Factual
Drug Design
Molecular Structure
Polycyclic Compounds - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diversity-oriented synthesis is an intriguing approach for creating structurally diverse compounds that cover the pharmaceutically relevant chemical space in an optimal way. On the other hand, an over-proportionally large number of drugs or lead structures originate from compounds isolated from natural sources. Thus, not surprisingly, an increasing number of combinatorial libraries are based on motifs resembling natural products. A particular aspect of many natural products is the presence of non-aromatic, polycyclic core structures. The fusion of several rings leads to geometrically well-defined structures and, thus, holds the promise of a high functional specialisation. In this review we present several actual examples of natural product-like libraries with non-aromatic polycyclic motifs based on naturally occurring compounds.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2005.04.002