Gamma-knife radiosurgery for the treatment of ovarian cancer metastatic to the brain

Central nervous system (CNS) metastases from an ovarian malignancy are uncommon. The long-term prognosis for these patients is poor, with studies reporting a mean survival of less than 12 months. We present three ovarian cancer patients who developed metastatic disease to the brain. All patients wer...

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Bibliographic Details
Published in:Gynecologic oncology 2005-06, Vol.97 (3), p.858-861
Main Authors: Brown, John V., Goldstein, Bram H., Duma, Christopher M., Rettenmaier, Mark A., Micha, John P.
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Brain metastases
Brain Neoplasms - secondary
Brain Neoplasms - surgery
Female
Gamma-knife radiosurgery
Humans
Long-term survival
Middle Aged
Ovarian cancer
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Radiosurgery
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Description
Summary:Central nervous system (CNS) metastases from an ovarian malignancy are uncommon. The long-term prognosis for these patients is poor, with studies reporting a mean survival of less than 12 months. We present three ovarian cancer patients who developed metastatic disease to the brain. All patients were heavily pre-treated prior to the development of CNS disease. Following detection of CNS disease, they all were treated with multi-modality therapy including gamma-knife radiosurgery (GKRS). At this time, one patient is alive at 26 months following treatment with GKRS. The second and third patients survived for 88 and 22 months respectively, before succumbing to their disease. Local control of ovarian cancer metastatic to the brain can be achieved in some patients with GKRS. Additional investigation into GKRS is warranted.
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2005.02.019