Giant cell tumour of bone in a cat with extraskeletal metastases: pathological and immunohistochemical study

A case of giant cell tumour of bone (GCT(b)) in the lung and in a subcutaneous mass located in the right flank, with a probable primary origin in the mid-diaphysis of the right tibia, was described in a 8-year-old female cat. Numerous multinucleated giant cells were homogeneously distributed among a...

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Bibliographic Details
Published in:Journal of veterinary medicine. Series A 2005-06, Vol.52 (5), p.225-229
Main Authors: Ferreras, M.C, Fuertes, M, Perez, V, Benavides, J, Garcia-Pariente, C, Reyes, L.E, Garcia-Marin, J.F
Format: Article
Language:English
Subjects:
Animals
bone diseases
Bone Neoplasms - diagnosis
Bone Neoplasms - pathology
Bone Neoplasms - veterinary
case studies
cat diseases
Cat Diseases - diagnosis
Cat Diseases - pathology
Cats
Diagnosis, Differential
Female
females
Giant Cell Tumor of Bone - diagnosis
Giant Cell Tumor of Bone - secondary
Giant Cell Tumor of Bone - veterinary
giant cells
immunohistochemistry
Immunohistochemistry - veterinary
Lung Neoplasms - diagnosis
Lung Neoplasms - secondary
Lung Neoplasms - veterinary
lungs
metastasis
Neoplasm Metastasis
neoplasms
pathophysiology
Soft Tissue Neoplasms - diagnosis
Soft Tissue Neoplasms - secondary
Soft Tissue Neoplasms - veterinary
tibia
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Summary:A case of giant cell tumour of bone (GCT(b)) in the lung and in a subcutaneous mass located in the right flank, with a probable primary origin in the mid-diaphysis of the right tibia, was described in a 8-year-old female cat. Numerous multinucleated giant cells were homogeneously distributed among a population of ovoid or spindle-shaped mononuclear cells. All of them were positive for vimentin suggesting a mesenchymal origin. Spindle-shaped tumour cells resemble fibroblastic cells, showing collagen fibres in their vicinity. Ovoid mononuclear cells are similar to macrophages, with a cytoplasm rich in electron-dense lysosomes. Multinucleated giant cells appear morphologically similar to osteoclasts. These findings are supported for the positive reaction to tartrate-resistant acid phosphatase (TRAP) and lysozyme, encountered only in ovoid and multinucleated giant cells. No immunoreactivity against human oestrogen receptors was observed in the nuclei of any neoplastic cells.
ISSN:0931-184X
1439-0442
DOI:10.1111/j.1439-0442.2005.00720.x