Xenon anaesthesia may preserve cardiovascular function in patients with heart failure

Background:  The hypothesis that xenon anaesthesia provided haemodynamic stability was tested in patients with heart failure in a prospective, randomized, single‐blind design. Methods:  Twenty‐six patients scheduled for implantation of a cardioverter‐defibrillator (ICD) received xenon 60–65% in oxyg...

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Published in:Acta anaesthesiologica Scandinavica 2005-07, Vol.49 (6), p.743-749
Main Authors: Baumert, J.-H., Falter, F., Eletr, D., Hecker, K. E., Reyle-Hahn, M., Rossaint, R.
Format: Article
Language:English
Subjects:
Aged
Anesthesia
Anesthesia, Inhalation
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Inhalation - therapeutic use
Biological and medical sciences
Cardiomyopathy, Dilated - complications
cardiovascular function
Cardiovascular Physiological Phenomena - drug effects
Defibrillators, Implantable
Echocardiography
Female
Heart Failure - diagnostic imaging
Heart Failure - drug therapy
Heart Failure - physiopathology
Heart Function Tests
Hemodynamics - drug effects
Humans
Male
Medical sciences
Middle Aged
Monitoring, Intraoperative
Myocardial Ischemia - complications
Prosthesis Implantation
Single-Blind Method
xenon
Xenon - therapeutic use
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Summary:Background:  The hypothesis that xenon anaesthesia provided haemodynamic stability was tested in patients with heart failure in a prospective, randomized, single‐blind design. Methods:  Twenty‐six patients scheduled for implantation of a cardioverter‐defibrillator (ICD) received xenon 60–65% in oxygen (xenon group, n = 12) or propofol 3 mg/kg/h (propofol group, n = 14), both combined with remifentanil 0.2 µg/kg/min. After induction of anaesthesia with etomidate and remifentanil, heart rate (HR), mean arterial pressure (MAP) and left ventricular ejection fraction (LVEF) were recorded. After 60 min of propofol or xenon anaesthesia, the same parameters were recorded. Results:  While HR decreased in both groups, MAP was unchanged with xenon (73 vs. 76 mmHg) and decreased with propofol (from 78 to 64 mmHg, P 
ISSN:0001-5172
1399-6576
DOI:10.1111/j.1399-6576.2005.00662.x