Outbreak of hepatitis C virus infection in an outpatient clinic

• Published in: Journal of gastroenterology and hepatology 2005-07, Vol.20 (7), p.1087-1093
• Main Authors: ISHIKAWA, TAKASHI, FUKUSHIMA, YASUSHI, SHIOBARA, YUJIRO, KISHIMOTO, TSUYOSHI, TANNO, SAKIKO, SHOJI, IKUO, SUZUKI, TETSURO, MATSUI, TAMANO, SHIMADA, YASUSHI, OHYAMA, TAKAAKI, NAGAI, RYOZO, MIYAMURA, TATSUO
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Cross Infection - epidemiology; Cross Infection - virology; Disease Outbreaks; Female; General aspects; Hepacivirus - genetics; Hepacivirus - immunology; Hepatitis C - epidemiology; Hepatitis C - virology; Hepatitis C Antibodies - analysis; hepatitis C virus; Human infectious diseases. Experimental studies and models; Human viral diseases; Humans; Immunoblotting; Infectious diseases; Japan - epidemiology; Male; Medical sciences; Middle Aged; nosocomial infection; outbreak; outpatient clinic; Outpatient Clinics, Hospital; Polymerase Chain Reaction; Retrospective Studies; Risk Factors; RNA, Viral - analysis; Viral diseases; Viral diseases of the digestive system; Viral hepatitis
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/j.1440-1746.2005.03883.x

Background:  From January through September 2001, seven patients were admitted to Fukaya Red Cross Hospital with typical clinical manifestations of acute hepatitis. Six were outpatients of the clinic, which is located near the hospital. An extensive survey of clinic outpatients conducted by the local health department revealed six more new acute hepatitis cases during this period. Methods:  A case control study was carried out to identify potential risk factors for infection. In total, 1946 outpatients with clinic records were scheduled to undergo hepatitis C virus (HCV)‐antibody testing. For the HCV‐Ab positive patients, HCV‐RNA was subtyped and quantified, and sequences of HCV hypervariable region 1 were determined. Results:  Ultimately, 12 patients with acute hepatitis and two asymptomatic subjects were found to be a part of this outbreak. HCV isolates were divided into three major groups using phylogenetic tree analysis. Only a past history of visiting the clinic was significantly associated with acute hepatitis. The timing of the parenteral medical procedure at the clinic and the onset of acute hepatitis strongly suggested association of the two events. Conclusions:  Our findings suggest that nosocomial HCV infection can occur in an outpatient clinic, even in countries where post‐transfusion hepatitis has been almost entirely eliminated.