Mechanical properties and osteoconductivity of porous bioactive titanium

Porous bioactive titanium implants (porosity of 40%) were produced by a plasma-spray method and subsequent chemical and thermal treatments of immersion in a 5 M aqueous NaOH solution at 60 °C for 24 h, immersion in distilled water at 40 °C for 48 h, and heating to 600 °C for 1 h. Compression strengt...

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Bibliographic Details
Published in:Biomaterials 2005-10, Vol.26 (30), p.6014-6023
Main Authors: Takemoto, Mitsuru, Fujibayashi, Shunshuke, Neo, Mashashi, Suzuki, Jun, Kokubo, Tadashi, Nakamura, Takashi
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Bone and Bones - metabolism
Bone and Bones - pathology
Bone Substitutes - chemistry
Coated Materials, Biocompatible - chemistry
Durapatite - chemistry
Femur - pathology
Hot Temperature
Male
Materials Testing
Mechanical properties
Microscopy, Electron, Scanning
Osseointegration
Osteoconduction
Osteointegration
Porous titanium
Prostheses and Implants
Rabbits
Surface Properties
Surface treatment
Temperature
Tensile Strength
Time Factors
Titanium - chemistry
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Summary:Porous bioactive titanium implants (porosity of 40%) were produced by a plasma-spray method and subsequent chemical and thermal treatments of immersion in a 5 M aqueous NaOH solution at 60 °C for 24 h, immersion in distilled water at 40 °C for 48 h, and heating to 600 °C for 1 h. Compression strength and bending strength were 280 MPa (0.2% offset yield strength 85.2 MPa) and 101 MPa, respectively. For in vivo analysis, bioactive and nontreated porous titanium cylinders were implanted into 6 mm diameter holes in rabbit femoral condyles. The percentage of bone–implant contact (affinity index) of the bioactive implants (BGs) was significantly larger than for the nontreated implants (CGs) at all postimplantation times (13.5 versus 10.5, 16.7 versus 12.7, 17.7 versus 10.2, 19.1 versus 7.8 at 2, 4, 8 and 16 weeks, respectively). The percentage of bone area ingrowth showed a significant increase with the BGs, whereas with the CGs it appeared to decrease after 4 weeks (10.7 versus 9.9, 12.3 versus 13.1, 15.2 versus 9.8, 20.6 versus 8.7 at 2, 4, 8 and 16 weeks, respectively). These results suggest that porous bioactive titanium has sufficient mechanical properties and biocompatibility for clinical use under load-bearing conditions.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2005.03.019