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The effects of growth hormone status on circulating levels of vascular growth factors

Summary Background  Vascular growth factors are important not only in angiogenesis but also for the maintenance of normal endothelial integrity and function. Elevated levels of vascular endothelial growth factor (VEGF), angiopoietin‐2, hepatocyte growth factor (HGF), endostatin and angiogenin have b...

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Published in:Clinical endocrinology (Oxford) 2005-07, Vol.63 (1), p.79-86
Main Authors: Silha, Josef V., Krsek, Michal, Hana, Vaclav, Marek, Josef, Weiss, Vladimir, Jezkova, Jana, Rosicka, Martina, Jarkovska, Zuzana, Murphy, Liam J.
Format: Article
Language:English
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Summary:Summary Background  Vascular growth factors are important not only in angiogenesis but also for the maintenance of normal endothelial integrity and function. Elevated levels of vascular endothelial growth factor (VEGF), angiopoietin‐2, hepatocyte growth factor (HGF), endostatin and angiogenin have been associated with endothelial dysfunction and atherosclerosis. Both acromegaly and growth hormone deficiency (GHD) are associated with endothelial dysfunction and changes in blood vessel morphology. Aim  To investigate the effect of GH status on the circulating levels of angiogenic factors. Design  We measured the levels of six endothelial growth modulators, four angiogenic growth factors and two inhibitors of angiogenesis in 35 untreated acromegalics, 36 untreated GH‐deficient subjects and 101 normal control subjects. Fifteen GH‐deficient subjects were also studied before and 1 year after treatment with GH. Results  Mean angiogenin concentrations were increased in acromegaly and decreased in GH‐deficient subjects compared to control subjects. Endostatin levels showed a similar pattern although the elevated levels in acromegalic subjects did not achieve statistical significance. Angiogenin and endostatin levels both correlated significantly with IGF‐I levels (R = 0·61, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2005.02303.x