Predicting protein function from sequence and structural data

When a protein's function cannot be experimentally determined, it can often be inferred from sequence similarity. Should this process fail, analysis of the protein structure can provide functional clues or confirm tentative functional assignments inferred from the sequence. Many structure-based...

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Bibliographic Details
Published in:Current opinion in structural biology 2005-06, Vol.15 (3), p.275-284
Main Authors: Watson, James D, Laskowski, Roman A, Thornton, Janet M
Format: Article
Language:English
Subjects:
Binding Sites
Computer Simulation
Databases, Protein
Models, Chemical
Models, Molecular
Protein Binding
Protein Conformation
Protein Interaction Mapping - methods
Proteins - analysis
Proteins - chemistry
Proteins - classification
Proteins - metabolism
Sequence Alignment - methods
Sequence Analysis, Protein - methods
Structure-Activity Relationship
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Summary:When a protein's function cannot be experimentally determined, it can often be inferred from sequence similarity. Should this process fail, analysis of the protein structure can provide functional clues or confirm tentative functional assignments inferred from the sequence. Many structure-based approaches exist (e.g. fold similarity, three-dimensional templates), but as no single method can be expected to be successful in all cases, a more prudent approach involves combining multiple methods. Several automated servers that integrate evidence from multiple sources have been released this year and particular improvements have been seen with methods utilizing the Gene Ontology functional annotation schema.
ISSN:0959-440X
1879-033X
DOI:10.1016/j.sbi.2005.04.003