DNA vaccines against enteric infections

The first DNA vaccines for prevention of infectious diseases were described in 1993 and have since been shown to generate protective humoral and cellular immune responses to numerous infectious agents. For enteric infections, protective immunity has been obtained with DNA vaccines against several en...

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Bibliographic Details
Published in:Vaccine 2006-05, Vol.24 (18), p.3705-3708
Main Author: Herrmann, John E.
Format: Article
Language:English
Subjects:
Administration, Oral
Animal models
Animals
Antigens
Applied microbiology
Bacteria
Bacterial Infections - prevention & control
Bacterial Infections - veterinary
Biolistics
Biological and medical sciences
Capsules
Clinical trials
Deoxyribonucleic acid
Disease
DNA
DNA vaccines
Enteric diseases
Fundamental and applied biological sciences. Psychology
Gastrointestinal Diseases - immunology
Gastrointestinal Diseases - prevention & control
Genetic Vectors
Humans
Infections
Infectious diseases
Influenza
Injections, Intramuscular
Intestinal Diseases, Parasitic - prevention & control
Intestinal Diseases, Parasitic - veterinary
Listeria
Listeria monocytogenes
Microbiology
Mortality
Plasmids
Proteins
Rotavirus
Salmonella
Studies
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, DNA - administration & dosage
Vaccines, DNA - immunology
Virus Diseases - prevention & control
Virus Diseases - veterinary
Viruses
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Description
Summary:The first DNA vaccines for prevention of infectious diseases were described in 1993 and have since been shown to generate protective humoral and cellular immune responses to numerous infectious agents. For enteric infections, protective immunity has been obtained with DNA vaccines against several enteric viral, bacterial, and parasitic agents. Inoculation of DNA vaccines has generally been by intramuscular injection or by gene gun delivery of vaccine DNA-coated gold microparticles into the skin. Administration of DNA vaccines by the oral route would target the vaccines to enteric mucosal tissues, as well as providing a convenient means for vaccine delivery. Orally administered plasmid DNAs encapsulated in polymeric microparticles or inserted in live bacterial vectors have been effective in animal models for rotavirus DNA vaccines and Listeria monocytogenes DNA vaccines, respectively. Human trials of enteric DNA vaccines have not been initiated, but trials of veterinary vaccines have shown promise.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.07.012