Supercritical fluid assisted impregnation of indomethacin into chitosan thermosets for controlled release applications

Supercritical carbon dioxide (sc-CO 2) was used to impregnate indomethacin (a non-steroidal anti-inflammatory drug) into chitosan thermosets for the preparation of controlled release formulations. The products were analyzed by a range of methods including powder X-ray diffraction (XRD) and scanning...

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Bibliographic Details
Published in:International journal of pharmaceutics 2006-06, Vol.315 (1), p.93-98
Main Authors: Gong, K., Darr, J.A., Rehman, I.U.
Format: Article
Language:English
Subjects:
Amorphous
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Biological and medical sciences
Carbon Dioxide
Chitosan
Chitosan - chemistry
Chitosan - therapeutic use
Cold Temperature
Delayed-Action Preparations - chemistry
Drug
General pharmacology
Impregnation
Indomethacin
Indomethacin - administration & dosage
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pressure
sc-CO 2
Spectrum Analysis
Supercritical fluid
Temperature
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Summary:Supercritical carbon dioxide (sc-CO 2) was used to impregnate indomethacin (a non-steroidal anti-inflammatory drug) into chitosan thermosets for the preparation of controlled release formulations. The products were analyzed by a range of methods including powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effects of the experimental temperature and pressure of the sc-CO 2 on the thermal behavior of chitosan–indomethacin drug composites (DCs) was investigated via differential scanning calorimeter (DSC). The interaction of chitosan and indomethacin after impregnation was then studied by Fourier transform infrared (FTIR) and Raman spectroscopy, respectively. Our results suggest that the supercritical fluid impregnation process results in indomethacin being amorphously dispersed within the chitosan matrix. FTIR data suggest that the aliphatic carbonyl group of indomethacin interacts with the NH 2 group of the chitosan backbone. In vitro dissolution studies (via UV–vis spectroscopy) reveal that the dissolution rate of indomethacin substantially increases after processing in sc-CO 2, particularly, under the experimental conditions 20.7 MPa and 70 °C.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2006.02.030