Generation of a bioartificial fibromuscular tissue with autoregenerative capacities for surgical reconstruction

Anecdotal clinical reports denote first tissue engineering applications entering medical practice. Currently it is still unknown, if these new types of implants will tolerate the specific needs in cancer patients undergoing postoperative chemo- and radiotherapy. We implemented a radiotherapy protoco...

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Bibliographic Details
Published in:Cytotherapy (Oxford, England) England), 2006, Vol.8 (2), p.178-183
Main Authors: Biancosino, C., Zardo, P., Walles, T., Wildfang, I., Macchiarini, P., Mertsching, H.
Format: Article
Language:English
Subjects:
Animals
Bioartificial Organs
Cell Survival - radiation effects
human
Humans
in vitro
Male
medical oncology
Muscle, Smooth - cytology
Muscle, Smooth - physiology
Muscle, Smooth - radiation effects
Radiotherapy - methods
Reconstructive Surgical Procedures - methods
Regeneration
Swine
Tissue engineering
Tissue Engineering - methods
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Summary:Anecdotal clinical reports denote first tissue engineering applications entering medical practice. Currently it is still unknown, if these new types of implants will tolerate the specific needs in cancer patients undergoing postoperative chemo- and radiotherapy. We implemented a radiotherapy protocol (cumulative dosis 40Gy) on generated human bioartificial fibromuscular tissues in vitro. We monitored tissue vitality during radiotherapy and tissue recovery (8 weeks follow up period) applying histological methods. The biopsy procedure and seeding techniques yielded a viable 3 dimensional bioartificial human tissue. Radiation resulted in immediate devitalization without destroying tissue integrity. The bioartificial tissue recovered entirely in vitro within 6 weeks. Bioartificial human implants appear applicable for surgical reconstruction in oncologic patients potentially facing postoperative radiotherapy.
ISSN:1465-3249
1477-2566
DOI:10.1080/14653240600621166