Synthesis of latanoprost diastereoisomers

A new synthesis of latanoprost diastereoisomers is described which utilizes a highly stereoselective Michael addition of higher‐order cuprate to a chiral cyclopentenone derived from G‐lactone in the crucial skeleton‐forming step. Chirality 17:S109–S113, 2005. © 2005 Wiley‐Liss, Inc.

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Bibliographic Details
Published in:Chirality (New York, N.Y.) N.Y.), 2005, Vol.17 (S1), p.S109-S113
Main Authors: Obadalová, Iva, Pilarčík, Tomáš, Slavíková, Markéta, Hájíček, Josef
Format: Article
Language:English
Subjects:
chiral cyclopentenone
Corey's alcohol
diastereoselective Michael addition
glaucoma
higher-order cuprate
prostaglandins
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Summary:A new synthesis of latanoprost diastereoisomers is described which utilizes a highly stereoselective Michael addition of higher‐order cuprate to a chiral cyclopentenone derived from G‐lactone in the crucial skeleton‐forming step. Chirality 17:S109–S113, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.20116