Transposition of Great Arteries Is Associated With Increased Carotid Artery Stiffness

Transposition of great arteries is the consequence of abnormal aorticopulmonary septation. Animal embryonic data indicate that septation and elastogenesis are related events, but human and clinical data are not available. We tested the hypothesis that large artery elastic function was impaired in pa...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2006-06, Vol.47 (6), p.1197-1202
Main Authors: Mersich, Beatrix, Studinger, Peter, Lenard, Zsuzsanna, Kadar, Krisztina, Kollai, Mark
Format: Article
Language:English
Subjects:
Adolescent
Adult
Arterial hypertension. Arterial hypotension
Arteries - surgery
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiac Surgical Procedures
Cardiology. Vascular system
Carotid Artery, Common - diagnostic imaging
Carotid Artery, Common - physiopathology
Case-Control Studies
Child
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Cross-Sectional Studies
Elasticity
Heart Atria - surgery
Humans
Male
Medical sciences
Metabolic diseases
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Pulsatile Flow
Transposition of Great Vessels - physiopathology
Transposition of Great Vessels - surgery
Ultrasonography
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Summary:Transposition of great arteries is the consequence of abnormal aorticopulmonary septation. Animal embryonic data indicate that septation and elastogenesis are related events, but human and clinical data are not available. We tested the hypothesis that large artery elastic function was impaired in patients with transposition of great arteries. We studied 34 patients aged 9 to 19 years, 12±3 years after atrial switch operation; 14 patients aged 7 to 9 years, 8±1 years after arterial switch operation; and 108 healthy control subjects matched for age. Carotid artery diastolic diameter and pulsatile distension were determined by echo wall-tracking; carotid blood pressure was measured by tonometry. Systolic pressure was higher and diastolic pressure was lower in patients than in controls. Patients with atrial and arterial switch repair were compared with their respective controls by 2-factor ANOVA. For patients with atrial switch repair versus control, stiffness index β was 4.9±1.5 versus 3.1±1.0 (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000218826.72592.e9