Flavin Adenine Dinucleotide As Precursor for NADH Electrocatalyst

The generation of a new electrocatalytic system for NADH after oxidizing flavin adenine dinucleotide (FAD) is shown. The oxidation is performed in alkaline medium until +1.4 V (Ag/AgCl) at graphite electrodes. The catalytic activity is ascribed to the electrooxidized moiety of FAD and not to quinone...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2005-07, Vol.77 (13), p.4286-4289
Main Authors: de-los-Santos-Álvarez, Noemí, de-los-Santos-Álvarez, Patricia, Lobo-Castañón, M. Jesús, Miranda-Ordieres, Arturo J, Tuñón-Blanco, Paulino
Format: Article
Language:English
Subjects:
Analytical chemistry
Catalysis
Chemistry
Electrochemical methods
Electrochemistry - methods
Electrodes
Exact sciences and technology
Flavin-Adenine Dinucleotide - chemistry
Graphite
Molecular Structure
NAD - chemistry
Oxidation-Reduction
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Summary:The generation of a new electrocatalytic system for NADH after oxidizing flavin adenine dinucleotide (FAD) is shown. The oxidation is performed in alkaline medium until +1.4 V (Ag/AgCl) at graphite electrodes. The catalytic activity is ascribed to the electrooxidized moiety of FAD and not to quinone surface groups. A comparison between this catalyst and that attributed to poly(FAD) (Karyakin, A. A.; Ivanova Y. N.; Revunova, K. V.; Karyakina, E. E. Anal. Chem. 2004, 76, 2004−2009.) is presented. It is concluded that the surface quinone groups generated during the strong anodization of the electrode in acidic medium at 2−2.5 V and not the poly(FAD) are responsible for the catalytic activity described in the above mentioned work.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac048545p