Plasma- and urine concentrations of nitrite/nitrate and cyclic Guanosinemonophosphate in intrauterine growth restricted and preeclamptic pregnancies

The Nitric Oxide (NO) system plays an important role in the establishment and maintenance of the feto-placental circulation. Research on the pathogenesis of preeclampsia in several studies has established the involvement of the NO-system in preeclampsia and fetal intrauterine growth restriction (IUG...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2006-06, Vol.274 (3), p.150-154
Main Authors: Schiessl, Barbara, Strasburger, Christian, Bidlingmaier, Martin, Mylonas, Ioannis, Jeschke, Udo, Kainer, Franz, Friese, Klaus
Format: Article
Language:English
Subjects:
Birth Weight
Cyclic GMP - blood
Cyclic GMP - metabolism
Cyclic GMP - urine
Female
Fetal Growth Retardation - metabolism
Humans
Infant, Newborn
Nitrates
Nitrates - blood
Nitrates - metabolism
Nitrates - urine
Nitric Oxide - metabolism
Nitrites - blood
Nitrites - metabolism
Nitrites - urine
Pathogenesis
Pre-Eclampsia - metabolism
Preeclampsia
Pregnancy
Pregnancy Outcome
Prospective Studies
Urine
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Summary:The Nitric Oxide (NO) system plays an important role in the establishment and maintenance of the feto-placental circulation. Research on the pathogenesis of preeclampsia in several studies has established the involvement of the NO-system in preeclampsia and fetal intrauterine growth restriction (IUGR). In the presented study we analyzed the urine and plasma concentrations of nitrite/nitrate, the stable endproducts of NO and its second messenger, cyclic Guanosinemonophosphate (cGMP) in normal, preeclamptic and IUGR pregnancies. In total 76 patients were investigated in a prospective study for repeated determination of plasma and urinary levels of nitrate/nitrite and cGMP: 49 patients with a normal course of pregnancy, 14 patients with fetal IUGR and 13 patients with preeclampsia were included into the study. Plasma and urine Nitrite/Nitrate-concentrations were determined using a Colorimetric Assay (Cayman Inc., USA), concentrations of the second messenger cGMP in plasma and urinary samples were determined with a J(125)-Radio-Immuno-Assay (ibl Inc., Germany). The Stat View Program (Abacus Concepts, Inc., Berkeley, CA, 1992-1998) was used for statistical analysis, a P value
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-006-0149-8