The effect of chronic exposure to highly aggressive mice on hippocampal gene expression of non-aggressive subordinates

Exposure to a chronic psychosocial stressor changes the behavioral and neuroendocrine response pattern and causes structural changes in the rodent hippocampus. However, the underlying molecular mechanism of these changes induced by chronic stress is largely unknown. Recently, it was shown that expos...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 2006-05, Vol.1089 (1), p.10-20
Main Authors: Feldker, Dorine E.M., Morsink, Maarten C., Veenema, Alexa H., Datson, Nicole A., Proutski, Vitali, Lathouwers, Desiree, de Kloet, E. Ronald, Vreugdenhil, Erno
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aggression - physiology
Anatomical correlates of behavior
Animals
Behavior, Animal - physiology
Behavioral psychophysiology
Biological and medical sciences
Brain
Cell Survival - genetics
Chronic Disease
CHUK/IKKα
Depression
Disease Models, Animal
Down-Regulation - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling
Gene Expression Regulation - physiology
Glucocorticoid
Hippocampus
Hippocampus - metabolism
Male
Medical sciences
Mice
Microarray
Mood disorders
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Neuronal Plasticity - genetics
NF-kappa B - genetics
NFκB
Oligonucleotide Array Sequence Analysis
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Ribosomes - genetics
Ribosomes - metabolism
Sensory contact stress
Signal Transduction - genetics
Social Dominance
Social Environment
Stress, Psychological - genetics
Stress, Psychological - metabolism
Time
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Exposure to a chronic psychosocial stressor changes the behavioral and neuroendocrine response pattern and causes structural changes in the rodent hippocampus. However, the underlying molecular mechanism of these changes induced by chronic stress is largely unknown. Recently, it was shown that exposure to a dominant highly aggressive mouse in the sensory contact model induced long-lasting stress symptoms in subordinate mice genetically selected for long attack latency (LAL mice). The aim of the present study was to study the effect of chronic stress on hippocampal gene expression in these subordinate LAL mice. GeneChips (Affymetrix) were used to compare gene expression profiles of LAL mice exposed to a sensory contact stressor for 25 days and their controls (one array per mouse, n = 5 per line). After this stress paradigm, 131 genes were found differentially expressed (P 
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2006.02.110