Direct Fabrication and Harvesting of Monodisperse, Shape-Specific Nanobiomaterials

A versatile “top-down” method for the fabrication of particles, Particle Replication In Nonwetting Templates (PRINT), is described which affords absolute control over particle size, shape, and composition. This technique is versatile and general enough to fabricate particles with a variety of chemic...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2005-07, Vol.127 (28), p.10096-10100
Main Authors: Rolland, Jason P, Maynor, Benjamin W, Euliss, Larken E, Exner, Ansley E, Denison, Ginger M, DeSimone, Joseph M
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biological and medical sciences
Biosensing Techniques - methods
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
General aspects
Materials science
Molecular biophysics
Nanoscale materials and structures: fabrication and characterization
Nanotechnology - instrumentation
Nanotechnology - methods
Nanotubes
Physics
Polyethylene Glycols - chemistry
Silicon - chemistry
Surface Properties
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Summary:A versatile “top-down” method for the fabrication of particles, Particle Replication In Nonwetting Templates (PRINT), is described which affords absolute control over particle size, shape, and composition. This technique is versatile and general enough to fabricate particles with a variety of chemical structures, yet delicate enough to be compatible with sophisticated biological agents. Using PRINT, we have fabricated monodisperse particles of poly(ethylene glycol diacrylate), triacrylate resin, poly(lactic acid), and poly(pyrrole). Monodisperse particle populations, ranging from sub-200 nm nanoparticles to complex micron-scale objects, have been fabricated and harvested. PRINT uses low-surface energy, chemically resistant fluoropolymers as molding materials, which eliminates the formation of a residual interconnecting film between molded objects. Until now, the presence of this film has largely prevented particle fabrication using soft lithography. Importantly, we have demonstrated that PRINT affords the simple, straightforward encapsulation of a variety of important bioactive agents, including proteins, DNA, and small-molecule therapeutics, which indicates that PRINT can be used to fabricate next-generation particulate drug-delivery agents.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja051977c