Tamsulosin treatment increases clinical success rate of single extracorporeal shock wave lithotripsy of renal stones

To design a randomized, no-treatment, controlled, prospective study to determine whether the administration of tamsulosin, as adjunctive medical therapy, increases the efficacy of one extracorporeal shock wave lithotripsy (ESWL) session to treat renal stones and decreases the use of analgesic drugs...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2005-07, Vol.66 (1), p.24-28
Main Authors: Gravina, Giovanni Luca, Costa, Alessia Mariagrazia, Ronchi, Piero, Galatioto, Giuseppe Paradiso, Angelucci, Adriano, Castellani, Daniele, Narcisi, Federico, Vicentini, Carlo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Combined Modality Therapy
Female
Humans
Kidney Calculi - therapy
Lithotripsy
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Prospective Studies
Remission Induction
Sulfonamides - therapeutic use
Urinary lithiasis
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Summary:To design a randomized, no-treatment, controlled, prospective study to determine whether the administration of tamsulosin, as adjunctive medical therapy, increases the efficacy of one extracorporeal shock wave lithotripsy (ESWL) session to treat renal stones and decreases the use of analgesic drugs after the procedure. A total of 130 patients underwent a single ESWL session to treat solitary radiopaque renal stones 4 to 20 mm in diameter. After treatment, all patients were randomly assigned to receive our standard medical therapy alone (controls) or in association with 0.4 mg tamsulosin daily for a maximum of 12 weeks. All 130 patients were followed up for 3 months or until an alternative treatment was given. Of the 130 patients, 78.5% of those receiving tamsulosin and 60% of controls had achieved clinical success at 3 months ( P = 0.037). When we stratified patients according to stone size, for those with a stone size larger than 10 mm, the success rate was significantly greater in the tamsulosin group ( P = 0.028). Renoureteral colic occurred in 76.9% of patients treated with standard therapy but in only 26.1% of those receiving tamsulosin ( P
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2005.01.013