Exhaled nitric oxide in healthy nonatopic school-age children: Determinants and height-adjusted reference values

Exhaled nitric oxide (FENO) was proposed as a marker of airway inflammation, but data about FENO in healthy children measured with standardized methods are so far limited. In order to assess the determinants of FENO in healthy children, we investigated a population‐based sample of school‐age childre...

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Published in:Pediatric pulmonology 2006-07, Vol.41 (7), p.635-642
Main Authors: Malmberg, L.P., Petäys, T., Haahtela, T., Laatikainen, T., Jousilahti, P., Vartiainen, E., Mäkelä, M.J.
Format: Article
Language:English
Subjects:
Adolescent
airway inflammation
atopy
Biological and medical sciences
Body Height
Child
children
Exhalation
exhaled nitric oxide
Female
Humans
Male
Medical sciences
Nitric Oxide - analysis
Pneumology
population studies
Reference Values
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Summary:Exhaled nitric oxide (FENO) was proposed as a marker of airway inflammation, but data about FENO in healthy children measured with standardized methods are so far limited. In order to assess the determinants of FENO in healthy children, we investigated a population‐based sample of school‐age children (n = 276) with a questionnaire, skin‐prick tests, spirometry, and the measurement of FENO. The FENO of 114 nonatopic and nonsmoking children considered healthy were analyzed with stepwise multiple regression analysis, which showed significant associations with age, standing height, weight, and body surface area, but not with gender. Height was found to be the best independent variable for the regression equation for FENO, which on average showed an increase in the height range of 120–180 cm from 7 to 14 ppb. In the random sample of children, increased FENO was associated with atopy (odds ratio, 9.0; 95% confidence interval, 3.9–21.1; P 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.20417