DNA Electrochemistry through the Base Pairs Not the Sugar−Phosphate Backbone

Using intercalated, covalently bound daunomycin as a redox probe, ground state charge transport in DNA films with a perturbation in base pair stacking was examined in comparison with breaks in the sugar−phosphate backbone. While the introduction of one or even two nicks in the sugar−phosphate backbo...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2005-07, Vol.127 (29), p.10160-10161
Main Authors: Liu, Tao, Barton, Jacqueline K
Format: Article
Language:English
Subjects:
Base Pair Mismatch
Base Pairing
Base Sequence
Biological and medical sciences
Daunorubicin - chemistry
DNA - chemistry
Electrochemistry
Fundamental and applied biological sciences. Psychology
Molecular biophysics
Physical chemistry in biology
Spectrophotometry, Ultraviolet
Sugar Phosphates - chemistry
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Summary:Using intercalated, covalently bound daunomycin as a redox probe, ground state charge transport in DNA films with a perturbation in base pair stacking was examined in comparison with breaks in the sugar−phosphate backbone. While the introduction of one or even two nicks in the sugar−phosphate backbone yields no detectable effect on electron transfer, a CA mismatch significantly attenuates the electron transfer yield. These results confirm that the base pair stack is the pathway for DNA-mediated charge transfer, not the sugar−phosphate backbone.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja053025c