Environmental Signals Elicit Multiple Responses in Dorsal Telencephalic Progenitors by Threshold-Dependent Mechanisms

Environmental signals including epidermal growth factor family members, Shh, fibroblast growth factor, and bone morphogenetic protein (BMP) can affect multiple processes during the development of the central nervous system, raising questions about the mechanisms that determine how these pleiotropic...

Full description

Saved in:
Bibliographic Details
Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2006-07, Vol.16 (suppl-1), p.i74-i81
Main Authors: Lillien, Laura, Gulacsi, Alexandra
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Aging - pathology
Aging - physiology
Animals
astrocyte
bone morphogenetic protein
Cell Aggregation
Cell Differentiation
Cell Movement
Differential Threshold
Environment
epidermal growth factor receptor
GABA
In Vitro Techniques
Mice
Nerve Net - cytology
Nerve Net - embryology
Neuronal Plasticity - physiology
Neurons - cytology
Neurons - physiology
Organogenesis - physiology
Rats
Rats, Sprague-Dawley
Receptor, Epidermal Growth Factor - metabolism
Signal Transduction - physiology
sonic hedgehog
stem cell
Stem Cells - cytology
Stem Cells - physiology
Telencephalon - cytology
Telencephalon - embryology
Tissue Distribution
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Environmental signals including epidermal growth factor family members, Shh, fibroblast growth factor, and bone morphogenetic protein (BMP) can affect multiple processes during the development of the central nervous system, raising questions about the mechanisms that determine how these pleiotropic signals are interpreted to elicit appropriate responses at specific times and locations. Here we address the idea that different thresholds of stimulation determine how progenitors in the dorsal telencephalon interpret these signals. One mechanism for achieving different thresholds of signaling is illustrated by the developmental increase in the level of epidermal growth factor receptor (EGFR) expression among a subset of progenitors in the late embryonic telencephalon. Another mechanism is illustrated by the antagonistic interaction of BMP with Shh, which can influence EGFR expression and neuron subtype choice. We focus on the similarities and differences in the control of these responses and address the possibility that the γ-aminobutyric acidergic neuron specification might be linked to progenitor expression of a higher level of EGFRs.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhj169