Is there an Association between ACE and CKMM Polymorphisms and Cycling Performance Status during 3-Week Races?

• Published in: International journal of sports medicine 2005-07, Vol.26 (6), p.442-447
• Main Authors: Lucía, A., Gómez-Gallego, F., Chicharro, J. L., Hoyos, J., Celaya, K., Córdova, A., Villa, G., Alonso, J. M., Barriopedro, M., Pérez, M., Earnest, C. P.
• Format: Article
• Language: English
• Subjects: Adult; Bicycling - physiology; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Gene Frequency - genetics; Genotype; Humans; Male; Physical Endurance - genetics; Physiology & Biochemistry; Polymorphism, Genetic - genetics; Reference Values; Renin - genetics; Running - physiology; Task Performance and Analysis; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
• ISSN: 0172-4622; 1439-3964
• DOI: 10.1055/s-2004-821108

Abstract In this paper, we examine the association between polymorphisms of the angiotensin-converting enzyme (ACE) and muscle-specific creatine kinase (CKMM) genes, and the actual performance status observed in professional cyclists capable of completing a classic tour stage race such as the Giro d'Italia, Tour de France, or Vuelta a España. To accomplish this, we compared the frequencies of the ACE and CKMM genotypes/alleles in 50 top-level Spanish professional cyclists that have completed at least one of these events to 119 sedentary controls, and 27 elite (Olympic-class) Spanish runners. The genetic polymorphism at the CK-MM locus was detected with the NCOI restriction endonuclease. The results of our study showed that the proportion of the DD genotype was higher in cyclists (50.0 %) than in the other two groups (p < 0.05), the proportion of the ID genotype was higher in controls (46.2 %) than in the other two groups (p < 0.05), and the proportion of the II genotype was higher in runners (40.7 %) than in the other two groups (p < 0.05). The proportion of the D allele was higher in both cyclists (65.0 %) and controls (57.6 %) than in runners (46.3 %) (p < 0.001), whereas the proportion of the I allele was higher in runners than in the other two groups (p < 0.001). No statistical differences were found for CKK-MM-NCOI. We conclude that in top-level professional cyclists capable of completing a classic 3-wk tour race, the frequency distribution of the D allele and the DD genotype seems to be higher than in other endurance athletes such as elite runners (in whom the I allele is especially frequent).