New Reference Intervals for Thyrotropin and Thyroid Hormones Based on National Academy of Clinical Biochemistry Criteria and Regular Ultrasonography of the Thyroid

The aim of our present study was to establish new reference intervals for thyrotropin (TSH) and thyroid hormones based on National Academy of Clinical Biochemistry (NACB) criteria and regular thyroid ultrasonography. We also assessed the effect of potentially confounding factors to modulate the limi...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2005-08, Vol.51 (8), p.1480-1486
Main Authors: Kratzsch, Juergen, Fiedler, Georg Martin, Leichtle, Alexander, Brugel, Matthias, Buchbinder, Susanne, Otto, Lothar, Sabri, Osama, Matthes, Gert, Thiery, Joachim
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Analytical, structural and metabolic biochemistry
Biochemistry
Biological and medical sciences
Body Mass Index
Contraceptives
Female
Fundamental and applied biological sciences. Psychology
Genetics
Hormones
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Reference Values
Sex Factors
Thyroid
Thyroid Gland - diagnostic imaging
Thyroid Hormones - blood
Thyrotropin - blood
Ultrasonography
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Summary:The aim of our present study was to establish new reference intervals for thyrotropin (TSH) and thyroid hormones based on National Academy of Clinical Biochemistry (NACB) criteria and regular thyroid ultrasonography. We also assessed the effect of potentially confounding factors to modulate the limits of these intervals. We investigated 870 apparently healthy persons and excluded, step by step, those with a family history of thyroid disease, pathologic thyroid ultrasonography results, and increased anti-thyroid peroxidase or anti-thyroglobulin antibodies. Accordingly, only 453 of the 870 persons in the entire group were finally included as reference collective. We measured serum concentrations of TSH, total and free thyroxine (T(4) and FT(4)), and total and free triiodothyronine (T(3) and FT(3)) of the whole and the reference collective on the ELECSYS system assays (Roche Diagnostics) and calculated the 2.5th and 97.5th percentiles for comparison. The calculated lower limit for TSH differed significantly between the reference intervals for healthy persons with an assessed normal thyroid gland vs the nonselected group of healthy blood donors. Age was the only independent factor and was significantly inversely associated with TSH (P
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2004.047399