A brief review of the use and utility of growth hormone stimulation testing in the NCGS: Do we need to do provocative GH testing?

True growth hormone deficiency (GHD) in childhood, while rare, has major clinical consequences. GHD is often associated with other pituitary hormone deficiencies, so these children may require multiple hormonal replacement and close clinical follow-up to optimize their outcome. Growth hormone stimul...

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Bibliographic Details
Published in:Growth hormone & IGF research 2005-07, Vol.15, p.21-25
Main Authors: Wilson, Darrell M., Frane, James
Format: Article
Language:English
Subjects:
Body Height
Growth Disorders - blood
Growth Disorders - diagnosis
Growth Hormone - deficiency
Growth hormone stimulation testing
Height standard deviation scores
Humans
Insulin tolerance test
Insulin-Like Growth Factor I - analysis
National Cooperative Growth Study
Predictive Value of Tests
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Summary:True growth hormone deficiency (GHD) in childhood, while rare, has major clinical consequences. GHD is often associated with other pituitary hormone deficiencies, so these children may require multiple hormonal replacement and close clinical follow-up to optimize their outcome. Growth hormone stimulation testing (GHST), as currently conducted, is not a reliable diagnostic tool. Both changes in growth hormone assay methodologies and increases in the diagnostic threshold contribute to the incorrect labeling of a substantial proportion of normal children as having idiopathic GHD. Fortunately, newer imaging technologies and laboratory tests form a more rational basis to diagnose true GHD. The use of GHST among GH-naive subjects (
ISSN:1096-6374
1532-2238
DOI:10.1016/j.ghir.2005.06.005