Diffusion tensor imaging (DTI) and tractography of the cerebellar projections to prefrontal and posterior parietal cortices: A study at 3T

Abstract Objectives Previous diffusion tensor imaging (DTI) studies have identified cerebellar pathways and supratentorial connections, but none of them have isolated cerebellar projections to prefrontal and posterior parietal cortices using tractography. The aim of our study was to identify and vis...

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Bibliographic Details
Published in:Journal of neuroradiology 2008-03, Vol.35 (1), p.42-50
Main Authors: Jissendi, P, Baudry, S, Balériaux, D
Format: Article
Language:English
Subjects:
Adult
Brain Mapping - methods
Cerebello-cerebellar circuitry
Cerebellum
Cerebellum - anatomy & histology
Cervelet
Cicuit cerebello-cerebral
Diffusion Magnetic Resonance Imaging
Diffusion tensor imaging
Female
Humans
Imagerie en tenseur de diffusion
Imaging, Three-Dimensional
Male
Middle Aged
Parietal Lobe - anatomy & histology
Prefrontal Cortex - anatomy & histology
Radiology
Tractographie
Tractography
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Summary:Abstract Objectives Previous diffusion tensor imaging (DTI) studies have identified cerebellar pathways and supratentorial connections, but none of them have isolated cerebellar projections to prefrontal and posterior parietal cortices using tractography. The aim of our study was to identify and visualize on 3D projections, as well as on 2D cross-sectional images, the cerebellar projections to prefrontal (PF) and posterior parietal (PP) cortices. Material and methods The study included 10 healthy volunteers, four males and six females aged 25 to 45 years (mean age 31 years). A DTI sequence was applied at 3 Tesla using diffusion sensitizing gradients in 32 directions. White matter tracts were reconstructed by applying a multiple ROI (region of interest) tractography technique. Results PF projections were obtained in all subjects. PP projections were obtained in six over 10 subjects. On 2D cross-sectional images, the tracts showed the same anatomical location in each ROI in all subjects. Conclusion This DTI study at 3T resulted in a selective and full visualization of cerebellar projections to PF and PP cortices for the first time and is introductive for further optimized and quantitative DTI study of these tracts.
ISSN:0150-9861
DOI:10.1016/j.neurad.2007.11.001