Synthesis and biological evaluation of type VI β-turn templated RGD peptidomimetics

We report the design, synthesis, and binding affinities of a family of cyclic RGD peptides attached to type VI β-turn scaffolds. The analogues prepared exhibit interesting binding data to the isolated receptors α vβ 3 and α vβ 5. The results demonstrate the utility of these type VI β-turn scaffolds...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2006-08, Vol.16 (15), p.3971-3974
Main Authors: Creighton, Christopher J., Du, Yanming, Santulli, Rosemary J., Tounge, Brett A., Reitz, Allen B.
Format: Article
Language:English
Subjects:
Beta turn
Biological and medical sciences
Medical sciences
Miscellaneous
Models, Molecular
Molecular Mimicry
Oligopeptides - chemical synthesis
Oligopeptides - chemistry
Oligopeptides - pharmacology
Peptidomimetic
Pharmacology. Drug treatments
RGD
Scaffold
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Summary:We report the design, synthesis, and binding affinities of a family of cyclic RGD peptides attached to type VI β-turn scaffolds. The analogues prepared exhibit interesting binding data to the isolated receptors α vβ 3 and α vβ 5. The results demonstrate the utility of these type VI β-turn scaffolds for the constraint of biologically relevant peptides.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.05.020