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Trace element status in Saudi patients with established atherosclerosis
Traditional coronary risk factors do not fully explain variations in the incidence of cardiovascular disease (CVD). Epidemiological studies have implicated perturbations in selenium, copper, and zinc metabolism in the aetiology of CVD. However, these studies have been principally undertaken in Cauca...
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| Published in: | Journal of trace elements in medicine and biology 2006-01, Vol.20 (2), p.105-114 |
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| container_end_page | 114 |
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| container_start_page | 105 |
| container_title | Journal of trace elements in medicine and biology |
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| creator | Alissa, Eman M. Bahjri, Suhad M. Ahmed, Waqar H. Al-ama, Nabeel Ferns, Gordon A.A. |
| description | Traditional coronary risk factors do not fully explain variations in the incidence of cardiovascular disease (CVD). Epidemiological studies have implicated perturbations in selenium, copper, and zinc metabolism in the aetiology of CVD. However, these studies have been principally undertaken in Caucasian populations, in whom trace element intake is generally sufficient.
We have measured serum and urine selenium, copper, and zinc; and superoxide dismutase, glutathione peroxidase, and lipid peroxide concentrations in 130 Saudi male subjects with established CVD, and 130 age-matched controls.
Diabetes mellitus, positive smoking habit (
p |
| doi_str_mv | 10.1016/j.jtemb.2005.10.004 |
| format | article |
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We have measured serum and urine selenium, copper, and zinc; and superoxide dismutase, glutathione peroxidase, and lipid peroxide concentrations in 130 Saudi male subjects with established CVD, and 130 age-matched controls.
Diabetes mellitus, positive smoking habit (
p<0.0001 for both), and hypertension (
p<0.05) were more prevalent among CVD patients. Urinary copper (
p<0.0001) and zinc (
p<0.05) were higher among controls. Serum selenium concentrations were lower among CVD patients (
p<0.001), and a high proportion (52%) had selenium levels below 79
μg/L compared to controls (22%) (
p<0.0001). Conditional logistic regression analysis, showed the characteristics differentiating CVD patients from controls were serum zinc (odds ratio (OR) 0.92, confidence interval (CI) 0.85–0.99,
p<0.05), serum copper/zinc ratio (OR 0.31, CI 0.10–0.96), serum selenium (OR 0.07, CI 0.02–0.31,
p<0.0001), and urine selenium (OR 3.34, CI 1.40–7.99,
p<0.01).
Measures of trace metals status appear to be associated with the risk of atherosclerosis in a Saudi male population.]]></description><identifier>ISSN: 0946-672X</identifier><identifier>EISSN: 1878-3252</identifier><identifier>DOI: 10.1016/j.jtemb.2005.10.004</identifier><identifier>PMID: 16785050</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Age Factors ; Aged ; Atherosclerosis ; Atherosclerosis - blood ; Atherosclerosis - urine ; Copper ; Copper - blood ; Copper - urine ; Demography ; Diet ; Glutathione Peroxidase - blood ; Glutathione Peroxidase - urine ; Humans ; Lipid Peroxides - blood ; Lipid Peroxides - urine ; Male ; Middle Aged ; Multivariate Analysis ; Risk Factors ; Saudi Arabia ; Selenium ; Selenium - blood ; Selenium - urine ; Superoxide Dismutase - blood ; Superoxide Dismutase - urine ; Trace Elements - blood ; Trace Elements - urine ; Zinc ; Zinc - blood ; Zinc - urine</subject><ispartof>Journal of trace elements in medicine and biology, 2006-01, Vol.20 (2), p.105-114</ispartof><rights>2005 Elsevier GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-f5e33ccf6568af5150a3a47289e19c9c5e62d8a15cc8a0ca681773b09a0cec643</citedby><cites>FETCH-LOGICAL-c357t-f5e33ccf6568af5150a3a47289e19c9c5e62d8a15cc8a0ca681773b09a0cec643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16785050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alissa, Eman M.</creatorcontrib><creatorcontrib>Bahjri, Suhad M.</creatorcontrib><creatorcontrib>Ahmed, Waqar H.</creatorcontrib><creatorcontrib>Al-ama, Nabeel</creatorcontrib><creatorcontrib>Ferns, Gordon A.A.</creatorcontrib><title>Trace element status in Saudi patients with established atherosclerosis</title><title>Journal of trace elements in medicine and biology</title><addtitle>J Trace Elem Med Biol</addtitle><description><![CDATA[Traditional coronary risk factors do not fully explain variations in the incidence of cardiovascular disease (CVD). Epidemiological studies have implicated perturbations in selenium, copper, and zinc metabolism in the aetiology of CVD. However, these studies have been principally undertaken in Caucasian populations, in whom trace element intake is generally sufficient.
We have measured serum and urine selenium, copper, and zinc; and superoxide dismutase, glutathione peroxidase, and lipid peroxide concentrations in 130 Saudi male subjects with established CVD, and 130 age-matched controls.
Diabetes mellitus, positive smoking habit (
p<0.0001 for both), and hypertension (
p<0.05) were more prevalent among CVD patients. Urinary copper (
p<0.0001) and zinc (
p<0.05) were higher among controls. Serum selenium concentrations were lower among CVD patients (
p<0.001), and a high proportion (52%) had selenium levels below 79
μg/L compared to controls (22%) (
p<0.0001). Conditional logistic regression analysis, showed the characteristics differentiating CVD patients from controls were serum zinc (odds ratio (OR) 0.92, confidence interval (CI) 0.85–0.99,
p<0.05), serum copper/zinc ratio (OR 0.31, CI 0.10–0.96), serum selenium (OR 0.07, CI 0.02–0.31,
p<0.0001), and urine selenium (OR 3.34, CI 1.40–7.99,
p<0.01).
Measures of trace metals status appear to be associated with the risk of atherosclerosis in a Saudi male population.]]></description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - urine</subject><subject>Copper</subject><subject>Copper - blood</subject><subject>Copper - urine</subject><subject>Demography</subject><subject>Diet</subject><subject>Glutathione Peroxidase - blood</subject><subject>Glutathione Peroxidase - urine</subject><subject>Humans</subject><subject>Lipid Peroxides - blood</subject><subject>Lipid Peroxides - urine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Risk Factors</subject><subject>Saudi Arabia</subject><subject>Selenium</subject><subject>Selenium - blood</subject><subject>Selenium - urine</subject><subject>Superoxide Dismutase - blood</subject><subject>Superoxide Dismutase - urine</subject><subject>Trace Elements - blood</subject><subject>Trace Elements - urine</subject><subject>Zinc</subject><subject>Zinc - blood</subject><subject>Zinc - urine</subject><issn>0946-672X</issn><issn>1878-3252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYMozjj6CwTpyl1r0jSPLlzI4AsGXDiCu5Cmt0xKOx2TVPHfmzoD7twk5OTcc-_9ELokOCOY8Js2awP0VZZjzKKSYVwcoTmRQqY0Z_kxmuOy4CkX-fsMnXnfYkwEk_kpmhEuJMMMz9Hj2mkDCXTQwzYkPugw-sRuk1c91jbZ6WCj7pMvGzYJxO-qs34DdaLDBtzgTTed1p-jk0Z3Hi4O9wK9Pdyvl0_p6uXxeXm3Sg1lIqQNA0qNaTjjUjeMMKypLkQuSyClKQ0DntdSE2aM1NhoLokQtMJlfIDhBV2g633uzg0fYxxI9dYb6Dq9hWH0iktc8kLwaKR7o4nzeQeN2jnba_etCFYTP9WqX35q4jeJkV-sujrEj1UP9V_NAVg03O4NEJf8tOCUN5GQgdo6MEHVg_23wQ88AoMl</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Alissa, Eman M.</creator><creator>Bahjri, Suhad M.</creator><creator>Ahmed, Waqar H.</creator><creator>Al-ama, Nabeel</creator><creator>Ferns, Gordon A.A.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>Trace element status in Saudi patients with established atherosclerosis</title><author>Alissa, Eman M. ; Bahjri, Suhad M. ; Ahmed, Waqar H. ; Al-ama, Nabeel ; Ferns, Gordon A.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-f5e33ccf6568af5150a3a47289e19c9c5e62d8a15cc8a0ca681773b09a0cec643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - urine</topic><topic>Copper</topic><topic>Copper - blood</topic><topic>Copper - urine</topic><topic>Demography</topic><topic>Diet</topic><topic>Glutathione Peroxidase - blood</topic><topic>Glutathione Peroxidase - urine</topic><topic>Humans</topic><topic>Lipid Peroxides - blood</topic><topic>Lipid Peroxides - urine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Risk Factors</topic><topic>Saudi Arabia</topic><topic>Selenium</topic><topic>Selenium - blood</topic><topic>Selenium - urine</topic><topic>Superoxide Dismutase - blood</topic><topic>Superoxide Dismutase - urine</topic><topic>Trace Elements - blood</topic><topic>Trace Elements - urine</topic><topic>Zinc</topic><topic>Zinc - blood</topic><topic>Zinc - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alissa, Eman M.</creatorcontrib><creatorcontrib>Bahjri, Suhad M.</creatorcontrib><creatorcontrib>Ahmed, Waqar H.</creatorcontrib><creatorcontrib>Al-ama, Nabeel</creatorcontrib><creatorcontrib>Ferns, Gordon A.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of trace elements in medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alissa, Eman M.</au><au>Bahjri, Suhad M.</au><au>Ahmed, Waqar H.</au><au>Al-ama, Nabeel</au><au>Ferns, Gordon A.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trace element status in Saudi patients with established atherosclerosis</atitle><jtitle>Journal of trace elements in medicine and biology</jtitle><addtitle>J Trace Elem Med Biol</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>20</volume><issue>2</issue><spage>105</spage><epage>114</epage><pages>105-114</pages><issn>0946-672X</issn><eissn>1878-3252</eissn><abstract><![CDATA[Traditional coronary risk factors do not fully explain variations in the incidence of cardiovascular disease (CVD). Epidemiological studies have implicated perturbations in selenium, copper, and zinc metabolism in the aetiology of CVD. However, these studies have been principally undertaken in Caucasian populations, in whom trace element intake is generally sufficient.
We have measured serum and urine selenium, copper, and zinc; and superoxide dismutase, glutathione peroxidase, and lipid peroxide concentrations in 130 Saudi male subjects with established CVD, and 130 age-matched controls.
Diabetes mellitus, positive smoking habit (
p<0.0001 for both), and hypertension (
p<0.05) were more prevalent among CVD patients. Urinary copper (
p<0.0001) and zinc (
p<0.05) were higher among controls. Serum selenium concentrations were lower among CVD patients (
p<0.001), and a high proportion (52%) had selenium levels below 79
μg/L compared to controls (22%) (
p<0.0001). Conditional logistic regression analysis, showed the characteristics differentiating CVD patients from controls were serum zinc (odds ratio (OR) 0.92, confidence interval (CI) 0.85–0.99,
p<0.05), serum copper/zinc ratio (OR 0.31, CI 0.10–0.96), serum selenium (OR 0.07, CI 0.02–0.31,
p<0.0001), and urine selenium (OR 3.34, CI 1.40–7.99,
p<0.01).
Measures of trace metals status appear to be associated with the risk of atherosclerosis in a Saudi male population.]]></abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>16785050</pmid><doi>10.1016/j.jtemb.2005.10.004</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Atherosclerosis Atherosclerosis - blood Atherosclerosis - urine Copper Copper - blood Copper - urine Demography Diet Glutathione Peroxidase - blood Glutathione Peroxidase - urine Humans Lipid Peroxides - blood Lipid Peroxides - urine Male Middle Aged Multivariate Analysis Risk Factors Saudi Arabia Selenium Selenium - blood Selenium - urine Superoxide Dismutase - blood Superoxide Dismutase - urine Trace Elements - blood Trace Elements - urine Zinc Zinc - blood Zinc - urine |
| title | Trace element status in Saudi patients with established atherosclerosis |
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