Comparative Efficacy of Stabilized Stannous Fluoride/Sodium Hexametaphosphate Dentifrice and Sodium Fluoride/Triclosan/Copolymer Dentifrice for the Prevention of Periodontitis in Xerostomic Patients: A 2‐Year Randomized Clinical Trial

• Published in: Journal of periodontology (1970) 2007-08, Vol.78 (8), p.1505-1514
• Main Authors: Papas, Athena, He, Tao, Martuscelli, Gianluca, Singh, Mabi, Bartizek, Robert D., Biesbrock, Aaron R.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local - therapeutic use; Biological and medical sciences; Cariostatic Agents - therapeutic use; Dentifrice; Dentifrices - therapeutic use; Dentistry; Double-Blind Method; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; Follow-Up Studies; Gingival Hemorrhage - prevention & control; Humans; Male; Medical sciences; Middle Aged; Non tumoral diseases; Otorhinolaryngology. Stomatology; Periodontal Attachment Loss - prevention & control; Periodontal Pocket - prevention & control; periodontitis; Periodontitis - prevention & control; Phosphates - therapeutic use; randomized clinical trial; root caries; Root Caries - prevention & control; Sodium Fluoride - therapeutic use; stannous fluoride; Tin Fluorides - therapeutic use; Tooth Remineralization - methods; Triclosan - therapeutic use; xerostomia; Xerostomia - complications
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1902/jop.2007.060479

Background: The primary objective of this study was to compare the efficacy of a stannous fluoride (SnF2) dentifrice relative to a positive control triclosan dentifrice for prevention of clinical attachment loss (CAL) in xerostomic patients. A secondary objective was to compare the dentifrices for root caries remineralization. Methods: This was a 2‐year, randomized, double‐masked, parallel‐group study. A 0.454% SnF2/sodium hexametaphosphate dentifrice was tested versus a positive control dentifrice (sodium fluoride/0.30% triclosan/copolymer) in 440 medication‐induced xerostomic adults identified in a 1‐year, run‐in phase (no treatment) as high risk for periodontitis and root caries. During the study phase, subjects were stratified based on gender and attachment level into two groups. Subjects brushed twice a day for 60 seconds using their assigned product. Clinical examinations including probing depth, attachment level, bleeding on probing, and root caries remineralization were performed at baseline and 1 and 2 years. Results: A total of 334 subjects were evaluable. During run‐in, average CAL relative to initial examination was 1.33 mm. Probing depth increased 0.95 mm. At year 2 in the treatment phase, attachment gain was 0.77 mm for the test group and 0.79 mm for the control group versus baseline. Probing depth decreased 0.57 mm for the test group, similar to the control group (0.53 mm). These changes versus baseline were statistically significant (P