Immunogenetics of pregnancy: Role of a 14-bp deletion in the maternal HLA-G gene in primiparous pre-eclamptic Brazilian women

Summary The etiology and pathogenesis of pre-eclampsia (PE) involve a combination of maternal–fetal genetic and immunologic factors. The immunologic maladaptation theory of PE predicts that the maternal immune system does not tolerate the semi-allogeneic fetus. Human leukocyte antigen-G (HLA-G) is e...

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Bibliographic Details
Published in:Human immunology 2007-08, Vol.68 (8), p.668-674
Main Authors: Vianna, Priscila, Dalmáz, Caroline Abrão, Veit, Tiago Degani, Tedoldi, Citânia, Roisenberg, Israel, Chies, José Artur Bogo
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Brazil
Female
Genotype
Histocompatibility Antigens Class I - genetics
Histocompatibility Antigens Class I - immunology
HLA Antigens - genetics
HLA Antigens - immunology
HLA-G Antigens
HLA-G polymorphism
Humans
Immunogenetics
Immunomodulation
Parity
Polymorphism, Genetic
Pre-eclampsia
Pre-Eclampsia - genetics
Pre-Eclampsia - immunology
Pre-Eclampsia - physiopathology
Pregnancy
Sequence Deletion
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Summary:Summary The etiology and pathogenesis of pre-eclampsia (PE) involve a combination of maternal–fetal genetic and immunologic factors. The immunologic maladaptation theory of PE predicts that the maternal immune system does not tolerate the semi-allogeneic fetus. Human leukocyte antigen-G (HLA-G) is expressed in some types of immune cells as well as in the fetal–maternal interface by trophoblasts, playing an immunoregulatory role. Here we have evaluated a 14-bp deletion polymorphism in the 3′-untranslated region of exon 8 of HLA-G gene in pregnant PE women and controls. HLA-G genotypes in both control and PE women were in Hardy-Weinberg equilibrium. The healthy pregnant and PE women had similar genotype frequencies ( p = 0.789). This was similarly observed when PE women were subgrouped accordingly to severity of disease ( p = 0.646). However, the primiparous PE women presented a tendency toward higher frequency of the 14-bp deletion allele (0.442) compared with the primiparous healthy women (0.286), p = 0.09. Our data suggest that the maternal 14-bp deletion of HLA-G is not associated with the risk for PE but that it could affect the development of PE in primiparous women.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2007.05.006