Evidence for the homeostatic regulation of induced beta cell mass expansion

Diabetes results from an insufficient insulin-secreting beta cell mass. Restoration of beta cell mass through pharmaceutically induced endogenous beta cell mass expansion may revolutionise diabetes therapy. However, it remains to be determined whether the induced beta cell mass expansion is under ho...

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Bibliographic Details
Published in:Diabetologia 2006-12, Vol.49 (12), p.2910-2919
Main Authors: LIPSETT, M. A, AUSTIN, E. B, CASTELLARIN, M. L, LEMAY, J, ROSENBERG, L
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biological and medical sciences
Blood & organ donations
Blood Glucose - metabolism
Cell Division
Cell Size
Cricetinae
Diabetes
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Hibernation
Homeostasis
Hypotheses
Insulin
Insulin - analysis
Insulin-Secreting Cells - cytology
Insulin-Secreting Cells - physiology
Laboratories
Male
Medical sciences
Mesocricetus
Metabolism
Ostomy
Pancreas
Pancreatic Ducts - physiology
Pancreatitis-Associated Proteins
Proteins
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Summary:Diabetes results from an insufficient insulin-secreting beta cell mass. Restoration of beta cell mass through pharmaceutically induced endogenous beta cell mass expansion may revolutionise diabetes therapy. However, it remains to be determined whether the induced beta cell mass expansion is under homeostatic regulation. Beta cell mass expansion rates were derived from three separate studies of continuous stimulation of islet neogenesis, including the partial duct obstruction of euglycaemic Syrian hamsters, administration of a pentadecapeptide with the same amino acid sequence as residues 104-118 of islet neogenesis-associated protein (INGAP(104-118)) to euglycaemic Syrian hamsters, as well as to euglycaemic CD-1 mice. The incidence of islet neogenesis, average beta cell size, and beta cell replication and apoptotic rates were determined. Partial duct obstruction led to a approximately 2.5-fold increase in endocrine tissue at day 56 (p
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-006-0428-8