Glucose homeostasis remains altered by acute caffeine ingestion following 2 weeks of daily caffeine consumption in previously non-caffeine-consuming males

Acute caffeine ingestion increases serum NEFA and plasma adrenaline and decreases insulin sensitivity. Although frequently suggested, it is not known if a tolerance to these alterations in glucose homeostasis is developed in habitual caffeine consumers. Our objective was to determine whether acute c...

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Bibliographic Details
Published in:British journal of nutrition 2007-09, Vol.98 (3), p.556-562
Main Authors: Dekker, Mark J., Gusba, Jenny E., Robinson, Lindsay E., Graham, Terry E.
Format: Article
Language:English
Subjects:
acute effects
Administration, Oral
adults
Biological and medical sciences
blood glucose
Blood Glucose - analysis
blood lipids
C-Peptide - blood
Caffeine
Caffeine - administration & dosage
carbohydrate metabolism
dosage
epidemiology
epinephrine
Epinephrine - blood
Fatty Acids, Nonesterified - blood
Feeding. Feeding behavior
free fatty acids
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
Glucose homeostasis
glucose tolerance
Glucose Tolerance Test - methods
homeostasis
Homeostasis - physiology
Humans
insulin
Insulin - blood
insulin resistance
Male
men
Oral glucose tolerance test
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Xanthine - blood
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Summary:Acute caffeine ingestion increases serum NEFA and plasma adrenaline and decreases insulin sensitivity. Although frequently suggested, it is not known if a tolerance to these alterations in glucose homeostasis is developed in habitual caffeine consumers. Our objective was to determine whether acute caffeine ingestion continued to alter insulin, glucose, NEFA and adrenaline during an oral glucose tolerance test (OGTT) following 14 d of caffeine consumption. Twelve caffeine-naive young males underwent four OGTTs over a 4-week period. Subjects ingested a gelatin-filled placebo (PLA) capsule on the first trial day and 5 mg caffeine/kg body weight on the remaining three trial days (day 0, day 7, day 14) before a 2 h OGTT. Following day 0 and day 7, subjects were given six dosages of 5 mg caffeine/kg to consume per d between trials. Serum insulin and blood glucose area under the curve (AUC) were significantly elevated (P 
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114507730738