Inflammatory proteins in patients with obstructive sleep apnea with and without daytime sleepiness

Excessive daytime sleepiness (EDS) is one of the most frequent symptoms in patients with obstructive sleep apnea syndrome (OSAS). However, not all patients with OSAS manifest EDS. The aim of this study was to assess whether differential circulatory levels of inflammatory mediators would account for...

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Bibliographic Details
Published in:Sleep & breathing 2007-09, Vol.11 (3), p.177-185
Main Authors: DE LA PENA BRAVO, Monica, SERPERO, Laura D, BARCELO, Antonia, BARBE, Ferran, AGUSTI, Alvar, GOZAL, David
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cohort Studies
Dinoprost - analogs & derivatives
Dinoprost - blood
Disorders of Excessive Somnolence - immunology
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Drug therapy
Female
Fundamental and applied biological sciences. Psychology
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
Humans
Inflammation Mediators - blood
Intercellular Adhesion Molecule-1 - blood
Interleukin-6 - blood
Male
Medical sciences
Middle Aged
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Nervous system (semeiology, syndromes)
Neurology
Oxidative Stress - physiology
Oxygen - blood
P-Selectin - blood
Polysomnography
Prospective Studies
Reference Values
Sleep apnea
Sleep Apnea, Obstructive - immunology
Sleep disorders
Sleep. Vigilance
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the upper aerodigestive tract
Tumor Necrosis Factor-alpha - blood
Vertebrates: nervous system and sense organs
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Summary:Excessive daytime sleepiness (EDS) is one of the most frequent symptoms in patients with obstructive sleep apnea syndrome (OSAS). However, not all patients with OSAS manifest EDS. The aim of this study was to assess whether differential circulatory levels of inflammatory mediators would account for differences in somnolence among patients with OSAS. Patients were prospectively recruited from referral patient cohort to the university hospital sleep center. A total of 50 consecutive patients with OSAS undergoing overnight polysomnography with or without EDS and 20 controls were evaluated. EDS was assessed using the Epworth sleepiness scale (ESS) and the multiple sleep latency test after overnight polysomnography. EDS was defined when the ESS was >10 and the mean sleep latency
ISSN:1520-9512
1522-1709
DOI:10.1007/s11325-007-0100-7