Incidence of new-onset diabetes and impaired fasting glucose in patients with recent myocardial infarction and the effect of clinical and lifestyle risk factors

• Published in: The Lancet (British edition) 2007-08, Vol.370 (9588), p.667-675
• Main Authors: Mozaffarian, Dariush, Dr, Marfisi, RosaMaria, MS, Levantesi, Giacomo, MD, Silletta, Maria G, MS, Tavazzi, Luigi, MD, Tognoni, Gianni, MD, Valagussa, Franco, MD, Marchioli, Roberto, MD
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Cardiovascular disease; Diabetes; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - prevention & control; Diet; Diet, Mediterranean; Female; Glucose; Glucose Intolerance - epidemiology; Glucose Intolerance - prevention & control; Heart attacks; Humans; Hypertension; Incidence; Internal Medicine; Italy - epidemiology; Kaplan-Meier Estimate; Life Style; Male; Middle Aged; Multivariate Analysis; Myocardial infarction; Myocardial Infarction - complications; Olive oil; Proportional Hazards Models; Prospective Studies; Risk Factors
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/S0140-6736(07)61343-9

Summary Background Individuals with diabetes are at higher risk of myocardial infarction than non-diabetics. However, much less is known about the incidence of, and risk factors for, development of diabetes and impaired fasting glucose in patients who have had a myocardial infarction. We set out to estimate this incidence and investigate whether lifestyle factors such as dietary habits might alter this risk. Methods We used prospectively obtained data for 8291 Italian patients with a myocardial infarction within the previous 3 months, who were free of diabetes (determined by medication use, a physician-reported diagnosis, or fasting glucose ≥7 mmol/L) at baseline. Incidence of new-onset diabetes (new diabetes medication or fasting glucose ≥7 mmol/L) and impaired fasting glucose (fasting glucose ≥6·1 mmol/L and