Influence of bone volume fraction and architecture on computed large-deformation failure mechanisms in human trabecular bone

Large-deformation bending and buckling have long been proposed as failure mechanisms by which the strength of trabecular bone can be affected disproportionately to changes in bone density, and thus may represent an important aspect of bone quality. We sought here to quantify the contribution of larg...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2006-12, Vol.39 (6), p.1218-1225
Main Authors: Bevill, Grant, Eswaran, Senthil K., Gupta, Atul, Papadopoulos, Panayiotis, Keaveny, Tony M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomechanical Phenomena
Biomechanics
Biomechanics. Biorheology
Bone and Bones - anatomy & histology
Bone and Bones - physiology
Bone strength
Cancellous bone
Finite deformation
Finite Element Analysis
Finite element modeling
Fractures, Bone - etiology
Fractures, Bone - pathology
Fractures, Bone - physiopathology
Fundamental and applied biological sciences. Psychology
Humans
In Vitro Techniques
Models, Biological
Risk Factors
Tissues, organs and organisms biophysics
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Summary:Large-deformation bending and buckling have long been proposed as failure mechanisms by which the strength of trabecular bone can be affected disproportionately to changes in bone density, and thus may represent an important aspect of bone quality. We sought here to quantify the contribution of large-deformation failure mechanisms on strength, to determine the dependence of these effects on bone volume fraction and architecture, and to confirm that the inclusion of large-deformation effects in high-resolution finite element models improves predictions of strength versus experiment. Micro-CT-based finite element models having uniform hard tissue material properties were created from 54 cores of human trabecular bone taken from four anatomic sites (age=70±11; 24 male, 27 female donors), which were subsequently biomechanically tested to failure. Strength predictions were made from the models first including, then excluding, large-deformation failure mechanisms, both for compressive and tensile load cases. As expected, strength predictions versus experimental data for the large-deformation finite element models were significantly improved (p
ISSN:8756-3282
1873-2763
DOI:10.1016/j.bone.2006.06.016