Genetic risk of depression and stress-induced negative affect in daily life

A bias to develop negative affect in response to daily life stressors may be an important depression endophenotype, but remains difficult to assess. To assess this mood bias endophenotype, uncontaminated by current mood, in the course of daily life. The experience sampling method was used to collect...

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Bibliographic Details
Published in:British journal of psychiatry 2007-09, Vol.191 (3), p.218-223
Main Authors: Wichers, Marieke, Myin-Germeys, Inez, Jacobs, Nele, Peeters, Frenk, Kenis, Gunter, Derom, Catherine, Vlietinck, Robert, Delespaul, Philippe, Van Os, Jim
Format: Article
Language:English
Subjects:
Activities of daily living
Adolescent
Adult
Affect
Affect (Psychology)
Bias
Co-twins
Compliance
Daily experiences
Depression
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - genetics
Depressive Disorder, Major - psychology
Diseases in Twins - diagnosis
Diseases in Twins - genetics
Diseases in Twins - psychology
Emotions
Female
Genetic Predisposition to Disease - genetics
Genetic susceptibility
Health Surveys
Humans
Liability
Life events
Life stress
Male
Medical diagnosis
Mental depression
Middle Aged
Monozygotic
Mood
Moods
Multiple births
Negative affect
Negative emotions
Personality Assessment
Phenotype
Phenotypes
Prospective Studies
Psychiatry
Risk Factors
Self evaluation
Stress, Psychological - complications
Stressful incidents
Twins
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Summary:A bias to develop negative affect in response to daily life stressors may be an important depression endophenotype, but remains difficult to assess. To assess this mood bias endophenotype, uncontaminated by current mood, in the course of daily life. The experience sampling method was used to collect multiple appraisals of daily life event-related stress and negative affect in 279 female twin pairs. Cross-twin, cross-trait associations between dailylife mood bias and DSM-IV depression were conducted. Probands whose co-twins were diagnosed with lifetime depression showed a stronger mood bias to stress than those with co-twins without such a diagnosis, independent of probands' current depressive symptoms and to a greater extent in monozygotic twins than in dizygotic twins. Genetic liability to depression is in part expressed as the tendency to display negative affect in response to minor stressors in daily life. This trait may represent a true depression endophenotype.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.106.032201