Effect of pantoprazole in older patients with erosive esophagitis

Several studies suggest that older adults with gastroesophageal reflux disease (GERD) are more likely to develop complications, including erosive esophagitis, but it is unclear whether erosive esophagitis is more difficult to treat in older patients. The purpose of this study was to determine if adu...

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Bibliographic Details
Published in:Diseases of the esophagus 2007-10, Vol.20 (5), p.411-415
Main Authors: DeVault, K. R., Morgenstern, D. M., Lynn, R. B., Metz, D. C.
Format: Article
Language:English
Subjects:
2-Pyridinylmethylsulfinylbenzimidazoles - therapeutic use
Aged
Anti-Ulcer Agents - therapeutic use
Double-Blind Method
elderly
Esophagitis, Peptic - drug therapy
esophagus
Female
gastroesophageal reflux
Humans
Male
Middle Aged
Nizatidine - therapeutic use
pantoprazole
proton pump
Time Factors
Treatment Outcome
Wound Healing
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Summary:Several studies suggest that older adults with gastroesophageal reflux disease (GERD) are more likely to develop complications, including erosive esophagitis, but it is unclear whether erosive esophagitis is more difficult to treat in older patients. The purpose of this study was to determine if adults ≥ 65 years with erosive esophagitis are more difficult to treat than younger adults. The study was a post hoc analysis of two double‐blind, randomized, multicenter trials of patients with erosive esophagitis. Patients received pantoprazole 40 mg once daily, nizatidine 150 mg twice daily or placebo. Patients were evaluated for endoscopic healing at 4 and 8 weeks. Patients recorded typical reflux symptoms using a daily diary to note presence or absence of symptoms. Results showed that 44, 13 and 11 patients ≥ 65 years and 210, 69, and 71 patients
ISSN:1120-8694
1442-2050
DOI:10.1111/j.1442-2050.2007.00642.x