Intestinal gas retention in patients with idiopathic slow-transit constipation

Patients with slow-transit constipation (STC) have delayed colonic transit for solid und liquid bowel contents but intestinal gas handling has not been studied so far. Different nutrients influence motor and sensory gut function. We hypothesized that, in patients with STC, alteration of regulatory m...

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Bibliographic Details
Published in:Digestive diseases and sciences 2007-10, Vol.52 (10), p.2667-2675
Main Authors: HERNANDO-HARDER, Ana Cristina, FRANKE, Andreas, WEDEL, Thilo, BÖTTNER, Martina, KRAMMER, Heinz-Juergen, VINCENZ SINGER, Manfred, HARDER, Hermann
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Colonic Diseases, Functional - diagnosis
Colonic Diseases, Functional - etiology
Colonic Diseases, Functional - physiopathology
Colonoscopy
Constipation - complications
Constipation - diagnosis
Constipation - physiopathology
Diagnosis, Differential
Drug Administration Routes
Duodenum
Female
Gases - metabolism
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Motility - drug effects
Gastrointestinal Motility - physiology
Gastrointestinal Transit - drug effects
Gastrointestinal Transit - physiology
Glucose - administration & dosage
Humans
Lipids - administration & dosage
Medical sciences
Middle Aged
Other diseases. Semiology
Sensation
Sodium Chloride - administration & dosage
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Sweetening Agents - administration & dosage
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Summary:Patients with slow-transit constipation (STC) have delayed colonic transit for solid und liquid bowel contents but intestinal gas handling has not been studied so far. Different nutrients influence motor and sensory gut function. We hypothesized that, in patients with STC, alteration of regulatory mechanisms may result in impaired intestinal gas dynamics. On 3 separate days, validated gas challenge was performed in 10 STC patients and 10 volunteers during duodenal saline, lipids, or intravenous glucose. During saline only 60% +/- 8% of gas was cleared by STC patients after 60-min gas infusion, vs. 91% +/- 2% by controls (P < 0.001). Acute hyperglycemia or lipids did not change intestinal gas dynamics in these patients (saline infusion), but compared to healthy subjects, significant intestinal gas retention occurred. In STC, disturbances of intestinal gas dynamics include basal intestinal gas retention, and this is virtually not affected by acute hyperglycemia or duodenal lipids.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-006-9671-6