Levels of Circulating Procoagulant Microparticles in Nonvalvular Atrial Fibrillation

Circulating procoagulant microparticles (MPs) arising from cell activation or fragmentation during apoptosis retain procoagulant properties and are increased in severe thrombotic states. We investigated whether circulating procoagulant MP levels would be increased in nonvalvular atrial fibrillation...

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Bibliographic Details
Published in:The American journal of cardiology 2007-09, Vol.100 (6), p.989-994
Main Authors: Ederhy, Stéphane, MD, Di Angelantonio, Emanuele, MD, MSc, Mallat, Ziad, MD, PhD, Hugel, Bénédicte, PhD, Janower, Sandra, MD, Meuleman, Catherine, MD, Boccara, Franck, MD, Freyssinet, Jean-Marie, PhD, Tedgui, Alain, PhD, Cohen, Ariel, MD, PhD
Format: Article
Language:English
Subjects:
Aged
Annexin A5 - blood
Apoptosis
Atrial Fibrillation - blood
Biological and medical sciences
Blood Coagulation Factors - analysis
Cardiac arrhythmia
Cardiac dysrhythmias
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular Diseases - blood
Case-Control Studies
Cells
Endothelial Cells - cytology
Endothelial Cells - metabolism
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Particle Size
Regression analysis
Risk Factors
Therapy
Thrombophilia - blood
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Summary:Circulating procoagulant microparticles (MPs) arising from cell activation or fragmentation during apoptosis retain procoagulant properties and are increased in severe thrombotic states. We investigated whether circulating procoagulant MP levels would be increased in nonvalvular atrial fibrillation (AF). Using a hospital case-control study design, circulating procoagulant MP levels were measured in 45 patients with permanent and/or persistent AF who were not receiving anticoagulant therapy and 90 age-matched control subjects (45 with cardiovascular risk factors and 45 without). Annexin V-positive MP levels (expressed as nanomoles per liter of phosphatidylserine equivalent) were higher in patients with AF (median 9.3, interquartile range 6.8 to 17.3 nmol/L) than in control subjects with cardiovascular risk factors (median 4.9, interquartile range 3.7 to 8.4 nmol/L) and control subjects without cardiovascular risk factors (median 3.2, interquantile range 2.3 to 4.6 nmol/L; p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2007.04.040