Expression of c-kit proto-oncogene product in breast cancer tissues

The published results on expression of c-kit in benign and malignant breast tissues vary. The immunohistochemical expression of c-kit proto-oncogene product in 52 invasive breast cancer tissues and 16 benign breast tumor (fibroadenoma) tissues was studied using anti-c-kit proto-oncogene product anti...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2007-06, Vol.24 (2), p.169-174
Main Authors: Eroğlu, Aydan, Sari, Aliye
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Antibodies
Benign
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
c-Kit protein
Estrogen receptors
Estrogens
Female
Fibroadenoma
Fibroadenoma - metabolism
Fibroadenoma - pathology
Humans
Immunohistochemistry
Invasiveness
Lymph nodes
Metastases
Middle Aged
Neoplasm Staging
Oncology
Progesterone receptors
Proto-Oncogene Proteins c-kit - metabolism
Proto-oncogenes
Statistical analysis
Tumors
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Summary:The published results on expression of c-kit in benign and malignant breast tissues vary. The immunohistochemical expression of c-kit proto-oncogene product in 52 invasive breast cancer tissues and 16 benign breast tumor (fibroadenoma) tissues was studied using anti-c-kit proto-oncogene product antibody. Its expression was evaluated by immunoreactive score (IRS). In breast cancer tissues, the mean IRS of c-kit proto-oncogene product expression was significantly increased compared to those of fibroadenoma (3.4 +/- 2 and 2.19 +/- 1.8, respectively,p = 0.035). The mean IRS of c-kit expression was higher in the group comprising estrogen (ER) positive tumor than in the group of ER negative (4.1 +/- 2.1 and 2.7 +/- 1.8, respectively,p = 0.012) but no statistically significant relationship was seen between the expression of c-kit proto-oncogene product and other clinicopathological parameters of breast cancer, including histologic type, tumor size, lymph node metastasis, distant metastasis, stage, progesterone receptor, c-erbB-2 expression, menopausal status and age of the patient (p > 0.05). Our results show that a high level of c-kit expression occurs frequently in invasive breast cancer, and its expression is associated with ER but unrelated to other clinico-pathological variables.
ISSN:1357-0560
1559-131X
DOI:10.1007/bf02698036