Single-Walled Carbon Nanotubes in the Intact Organism:  Near-IR Imaging and Biocompatibility Studies in Drosophila

The ability of near-infrared fluorescence imaging to detect single-walled carbon nanotubes (SWNTs) in organisms and biological tissues has been explored using Drosophila melanogaster (fruit flies). Drosophila larvae were raised on food containing ∼10 ppm of disaggregated SWNTs. Their viability and g...

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Bibliographic Details
Published in:Nano letters 2007-09, Vol.7 (9), p.2650-2654
Main Authors: Leeuw, Tonya K, Reith, R. Michelle, Simonette, Rebecca A, Harden, Mallory E, Cherukuri, Paul, Tsyboulski, Dmitri A, Beckingham, Kathleen M, Weisman, R. Bruce
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Biocompatible Materials - administration & dosage
Biocompatible Materials - pharmacokinetics
Biological and medical sciences
Biotechnology
Cross-disciplinary physics: materials science
rheology
Drosophila melanogaster
Drosophila melanogaster - chemistry
Drosophila melanogaster - drug effects
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Materials science
Methods. Procedures. Technologies
Nanoscale materials and structures: fabrication and characterization
Nanotubes
Nanotubes, Carbon - chemistry
Organ Specificity
Others
Physics
Spectrophotometry, Infrared - methods
Tissue Distribution
Various methods and equipments
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Summary:The ability of near-infrared fluorescence imaging to detect single-walled carbon nanotubes (SWNTs) in organisms and biological tissues has been explored using Drosophila melanogaster (fruit flies). Drosophila larvae were raised on food containing ∼10 ppm of disaggregated SWNTs. Their viability and growth were not reduced by nanotube ingestion. Near-IR nanotube fluorescence was imaged from intact living larvae, and individual nanotubes in dissected tissue specimens were imaged, structurally identified, and counted to estimate a biodistribution.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl0710452