Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe

Abstract This investigation highlighted the risk of cancer in 8074 HIV-infected people and in 2875 transplant recipients in Italy and France. Observed and expected numbers of cancer were compared through sex- and age-standardised incidence ratios (SIRs) and 95% confidence intervals (CIs). After 15 y...

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Published in:European journal of cancer (1990) 2007-09, Vol.43 (14), p.2117-2123
Main Authors: Serraino, Diego, Piselli, Pierluca, Busnach, Ghil, Burra, Patrizia, Citterio, Franco, Arbustini, Eloisa, Baccarani, Umberto, De Juli, Emanuela, Pozzetto, Ubaldo, Bellelli, Stefania, Polesel, Jerry, Pradier, Christian, Maso, Luigino Dal, Angeletti, Claudio, Carrieri, Maria Patrizia, Rezza, Giovanni, Franceschi, Silvia
Format: Article
Language:English
Subjects:
Acquired immunodeficiency
Adult
Aged
Biological and medical sciences
Cancer
Cohort Studies
Female
France
France - epidemiology
Hematology, Oncology and Palliative Medicine
HIV Infections - complications
HIV Infections - epidemiology
HIV-infection
Humans
Immunosuppression - adverse effects
Italy
Italy - epidemiology
Male
Medical sciences
Middle Aged
Neoplasms - epidemiology
Neoplasms - etiology
Organ transplantation
Pharmacology. Drug treatments
Risk Factors
SIR
Transplantation - adverse effects
Tumors
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Summary:Abstract This investigation highlighted the risk of cancer in 8074 HIV-infected people and in 2875 transplant recipients in Italy and France. Observed and expected numbers of cancer were compared through sex- and age-standardised incidence ratios (SIRs) and 95% confidence intervals (CIs). After 15 years of follow-up, the cumulative probability of cancer was 14.7% in transplant recipients and 13.3% in HIV-positives. The SIRs for all cancers were 9.8 in HIV-positives and 2.2 in transplants. Kaposi’s sarcoma (SIR = 451 in HIV-positives, 125 in transplants) and non-Hodgkin lymphoma (SIR = 62 and 11.1, respectively) were the most common cancers. A significantly increased SIR for liver cancer also emerged in both groups. The risk of lung cancer was significantly elevated in heart transplant recipients (SIR = 2.8), and of borderline statistical significance in HIV-positive people (95% CI:0.9–2.8). Immune depression entails a two-fold increased overall risk of cancers, mainly related to cancers associated with a viral aetiology.
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2007.07.015