Epididymal Stone Formation and Decreased Sperm Production in Roosters Vaccinated with a Killed Strain of Avian Infectious Bronchitis Virus

Our objective was to determine if vaccination with killed avian infectious bronchitis virus (AIBV) causes epididymal calcium stones in the rooster as is seen following vaccination with live attenuated AIBV. Specific-pathogen-free roosters were divided into three groups: nonvaccinated (NONVAC), live...

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Bibliographic Details
Published in:Avian diseases 2006-12, Vol.50 (4), p.594-598
Main Authors: Boltz, David A, Zimmerman, Claire R, Nakai, Masaaki, Bunick, David, Scherba, Gail, Bahr, Janice M
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Viral
Avian infectious bronchitis virus
Calculi - veterinary
Chickens - virology
Coronavirus Infections - prevention & control
Enzyme linked immunosorbent assay
Epididymis
Epididymis - pathology
Epithelial cells
Histology
Infectious bronchitis virus
Infectious bronchitis virus - immunology
Infertility, Male
killed AIBV
Male
Organ Size
Poultry Diseases - immunology
Poultry Diseases - virology
Regular
Spermatozoa
Spermatozoa - physiology
stones
Testes
Testicular Diseases - veterinary
Testis - pathology
Vaccination
Viral Vaccines - adverse effects
Viruses
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Summary:Our objective was to determine if vaccination with killed avian infectious bronchitis virus (AIBV) causes epididymal calcium stones in the rooster as is seen following vaccination with live attenuated AIBV. Specific-pathogen-free roosters were divided into three groups: nonvaccinated (NONVAC), live attenuated AIBV–vaccinated (LVAC), and killed AIBV–vaccinated (KVAC) groups. Roosters were vaccinated at 2, 6, 10, and 14 wk of age and the epididymal region was observed at 27 wk of age. Epididymal stones were present in 13% of NONVAC, 50% of KVAC, and 64% of LVAC roosters. Histologically, immune cells were seen in the interstitium of efferent ductules containing stones. We conclude that use of a killed vaccine does not reduce the incidence of epididymal stones.
ISSN:0005-2086
1938-4351
DOI:10.1637/7654-052506R.1