Caloric restriction and human longevity : what can we learn from the Okinawans?

Caloric (or dietary) restriction (CR) extends lifespan and lowers risk for age associated diseases in a phylogenetically diverse group of species. Whether prolonged CR increases average or maximum lifespan or promotes a more youthful physiology in humans at advanced ages is not yet known. However, a...

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Bibliographic Details
Published in:Biogerontology (Dordrecht) 2006-06, Vol.7 (3), p.173-177
Main Authors: WILLCOX, D. Craig, WILLCOX, Bradley J, TODORIKI, Hidemi, CURB, J. David, SUZUKI, Makoto
Format: Article
Language:English
Subjects:
Aging
Aging - physiology
Biological and medical sciences
Caloric Restriction - statistics & numerical data
Clinical Trials as Topic - statistics & numerical data
Development. Metamorphosis. Moult. Ageing
Eating - physiology
Fundamental and applied biological sciences. Psychology
Humans
Japan - epidemiology
Longevity - physiology
Population Dynamics
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Caloric (or dietary) restriction (CR) extends lifespan and lowers risk for age associated diseases in a phylogenetically diverse group of species. Whether prolonged CR increases average or maximum lifespan or promotes a more youthful physiology in humans at advanced ages is not yet known. However, available epidemiological evidence indicates that CR may already have contributed to an extension of average and maximum life span in one human population and appears to have lowered risk for age associated chronic diseases in other human populations. We review the human studies in the context of a special human population, older Okinawans, who appear to have undergone a mild form of prolonged CR for about half their adult lives.
ISSN:1389-5729
1573-6768
DOI:10.1007/s10522-006-9008-z