Gender-specific effect of overexpression of sFlt-1 in pregnant mice on fetal programming of blood pressure in the offspring later in life

Objective The purpose of this study was to determine whether fetal programming of adult blood pressure is altered in a previously characterized mouse model of preeclampsia that was induced by sFlt-1. Study Design CD-1 mouse mothers at day 8 of gestation were injected with an adenovirus carrying Flt...

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Published in:American journal of obstetrics and gynecology 2007-10, Vol.197 (4), p.418.e1-418.e5
Main Authors: Lu, Fangxian, MD, Bytautiene, Egle, MD, Tamayo, Esther, Gamble, Phyllis, Anderson, Garland D., MD, Hankins, Gary D.V., MD, Longo, Monica, MD, PhD, Saade, George R., MD
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Birth Weight - genetics
Birth Weight - physiology
Blood Pressure - physiology
CD-1 mice
developmental origin
Female
Fetal Development - physiology
fetal programming
Male
Mice
Obstetrics and Gynecology
preeclampsia
Pregnancy
Random Allocation
Sex Factors
sFlt-1
Telemetry
Transfection
Vascular Endothelial Growth Factor Receptor-1 - biosynthesis
Vascular Endothelial Growth Factor Receptor-1 - genetics
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Summary:Objective The purpose of this study was to determine whether fetal programming of adult blood pressure is altered in a previously characterized mouse model of preeclampsia that was induced by sFlt-1. Study Design CD-1 mouse mothers at day 8 of gestation were injected with an adenovirus carrying Flt 1-3 (109 plaque-forming units) or with an adenovirus carrying mFc as control (109 plaque-forming units). The resulting pups were followed until 6 months of age, at which time blood pressure (BP) was recorded continuously for 6 days. The offspring weight was also recorded from weaning until adulthood. Results BP was significantly higher in the male offspring that were born to sFlt-1–treated mothers compared with the controls. Male offspring from sFlt-1–treated mothers were significantly smaller from weaning until adulthood. However, there were no significant differences in BP and postweaning weight in female offspring between the 2 groups. Conclusion Our findings highlight the role of the intrauterine environment in the developmental origin of adult disease.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2007.06.064