Tissue Factor: A Critical Role in Inflammation and Cancer

A series of coordinated enzymatic reactions takes place in the body whenever blood clots. The major physiological initiator of these reactions is a membrane-bound glycoprotein known as tissue factor (TF), which is normally separated from the bloodstream by the vascular endothelium. Bleeding, caused...

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Bibliographic Details
Published in:Biological research for nursing 2007-10, Vol.9 (2), p.97-107
Main Authors: Lwaleed, Bashir A., Cooper, Alan J., Voegeli, David, Getliffe, Kathryn
Format: Article
Language:English
Subjects:
Biomarkers
Blood Coagulation - physiology
Humans
Inflammation - immunology
Neoplasms - immunology
Nursing
Thromboplastin - immunology
Thromboplastin - metabolism
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Summary:A series of coordinated enzymatic reactions takes place in the body whenever blood clots. The major physiological initiator of these reactions is a membrane-bound glycoprotein known as tissue factor (TF), which is normally separated from the bloodstream by the vascular endothelium. Bleeding, caused by injury or tissue damage, activates a complex enzyme cascade as TF becomes exposed to the bloodstream. In disease states, leukocytes or the vascular endothelium may abnormally express TF to cause intravascular coagulation. The blood-coagulation cascade is also relevant to diseases such as hemophilia, in which patients are deficient in blood proteins necessary for clotting, and is linked to vascular diseases such as heart attack and stroke, in which clotting can lead to the occlusion of blood vessels. Coagulation is also activated in inflammation and cancer. In this article, we discuss characteristics of TF and review its role in inflammation and cancer.
ISSN:1099-8004
1552-4175
DOI:10.1177/1099800407305733