Diabetes insipidus revealing chronic myelomonocytic leukemia

Central diabetes insipidus is most frequently reported to occur after a trauma from surgery or accident. However, between 30 and 50% of cases are considered idiopathic. It's a rare complication of myelodysplastic syndrome. A 61-year-old patient presented central diabetes insipidus revealing, 17...

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Bibliographic Details
Published in:La revue de medecine interne 2007-10, Vol.28 (10), p.698-700
Main Authors: Graffin, B, Bernard, P, Landais, C, Gisserot, O, Aletti, M, Leyral, G, Paris, J-F, Carli, P
Format: Article
Language:eng ; fre
Subjects:
Chromosomes, Human, Pair 7 - genetics
Diabetes Insipidus - diagnosis
Diagnosis, Differential
Fatal Outcome
Humans
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myelomonocytic, Chronic - diagnosis
Male
Middle Aged
Monosomy - diagnosis
Monosomy - genetics
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Summary:Central diabetes insipidus is most frequently reported to occur after a trauma from surgery or accident. However, between 30 and 50% of cases are considered idiopathic. It's a rare complication of myelodysplastic syndrome. A 61-year-old patient presented central diabetes insipidus revealing, 17 months before, chronic myelomonocytic leukemia. Cytogenetics studies revealed monosomy 7. Acute myeloid leukemia appears 3 months after training rapid patient's death. Blood examination is necessary before to conclude idiopathic central diabetes insipidus. The discovery of chronic myelomonocytic leukemia implicates a rapid managing before its possible acute myeloid leukemia transformation. Indeed, prognosis of central diabetes insipidus and acute myeloid leukemia associated, in presence of monosomy 7, is very poor.
ISSN:0248-8663
DOI:10.1016/j.revmed.2007.05.027