PREVALENCE OF VIRAL AND MYCOBACTERIAL CO-INFECTIONS IN PERINATALLY HIV-INFECTED CHILDREN

The progression of HIV disease may be affected by co-infection with other viruses. This study investigates the prevalence of Epstein-Barr virus (EBV); cytomegalovirus (CMV); herpes simplex virus (HSV) types 1 and 2; hepatitis A, B, and C (HA, HB, HC); and tuberculosis in perinatally HIV-infected chi...

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Bibliographic Details
Published in:Fetal and pediatric pathology 2006-01, Vol.25 (6), p.321-331
Main Authors: Bowser, Corinna S., Kaye, Jean, Leier, Tim U., Chorney, Valeriy, Nathawad, Rita, Chernichenko, Natalya, Shin, Ann, Pragaspathy, Bhavadarani, Moallem, Jack
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
CMV
EBV
Female
hepatitis
herpes
HIV
HIV Infections - complications
HIV Infections - transmission
Humans
Immunoassay
Infectious Disease Transmission, Vertical
Luminescent Measurements
Male
Mycobacterium Infections - complications
Mycobacterium Infections - epidemiology
Pregnancy
Prevalence
tuberculosis
Urban Population
Virus Diseases - complications
Virus Diseases - epidemiology
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Summary:The progression of HIV disease may be affected by co-infection with other viruses. This study investigates the prevalence of Epstein-Barr virus (EBV); cytomegalovirus (CMV); herpes simplex virus (HSV) types 1 and 2; hepatitis A, B, and C (HA, HB, HC); and tuberculosis in perinatally HIV-infected children. Electrochemiluminescence Immunoassay (EIA) against EBV, CMV, HSV 1 and 2, HAV, HBV, HCV, and skin testing with purified protein derivative was performed on 45 perinatally HIV-infected children. CMV was positive in 51%, EBV in 93.3%, HSV-1 in 62.2%, HSV-2 in 48.9%, HAV in 15.6%, HBV and HCV in 6.7 % and PPD in 0 %. HSV-2 prevalence was higher in females and Hispanics. The prevalence of CMV, EBV, HSV-1, and tuberculosis was equivalent to rates reported in the general population. Prevalence of HSV-2 was significantly higher than in the general population (p < 0.001). Higher rates of HSV-2 infection and hepatitis may be secondary to high maternal co-infection rate and subsequent vertical transmission.
ISSN:1551-3815
1551-3823
DOI:10.1080/15513810701209553