When Does the Brain Inform the Eyes Whether and Where to Move? an EEG Study in Humans

The current study addressed when in the course of stimulus processing, and in what brain areas, activity occurs that supports the interpretation of cues that signal the appropriateness of different and competing behaviors. Twelve subjects completed interleaved no-go–, pro-, and antitrials, whereas 6...

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Bibliographic Details
Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2007-11, Vol.17 (11), p.2634-2643
Main Authors: Clementz, Brett A., Brahmbhatt, Shefali B., McDowell, Jennifer E., Brown, Ryan, Sweeney, John A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
antisaccades
Attention - physiology
Brain Mapping
EEG
Electroencephalography - methods
executive control
Eye Movements - physiology
Female
Humans
no go
prefrontal cortex
Prefrontal Cortex - physiology
response selection
saccades
Task Performance and Analysis
Visual Cortex - physiology
Visual Perception - physiology
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Summary:The current study addressed when in the course of stimulus processing, and in what brain areas, activity occurs that supports the interpretation of cues that signal the appropriateness of different and competing behaviors. Twelve subjects completed interleaved no-go–, pro-, and antitrials, whereas 64-channel electroencephalography was recorded. Principle component and distributed source analyses were used to evaluate the spatial distribution and time course of cortical activity supporting cue evaluation and response selection. By 158 ms poststimulus, visual cortex activity was lower for no-go trials than it was for both pro- and antitrials, consistent with an early sensory filter on the no-go cue. Prefrontal cortex (PFC) activity at 158 ms was highest during antitrials, consistent with this brain region's putative involvement in executive control. At 204 ms poststimulus, however, PFC activity was the same for pro- and antitrials, consistent with an ostensible role in response selection. PFC activity at 204 ms also was robustly inversely correlated (r = −0.75) with visual cortex activity on antitrials, perhaps indicating top-down modulation of early sensory processing that would decrease the probability of an error response. These data highlight how a distributed neural architecture supports the evaluation of stimuli and response choices.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhl171