Ghrelin does not regulate the GH response to insulin-induced hypoglycaemia in children but could be involved in the regulation of cortisol secretion

Summary Objective  Ghrelin activates the growth hormone secretagogue receptor GHS‐R. It strongly stimulates GH secretion and has a role in energy homeostasis. The relationship between plasma ghrelin and cortisol levels during insulin‐induced hypoglycaemia in prepubertal and pubertal children has not...

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Published in:Clinical endocrinology (Oxford) 2007-01, Vol.66 (1), p.143-147
Main Authors: Huber, J., Reiterer, E. E., Sudi, K., Gallistl, S., Friedl, K., Weinhandl, G., Aigner, R., Borkenstein, M. H.
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Analysis of Variance
Biological and medical sciences
Body Height
Body Mass Index
Body Weight
Child
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Ghrelin
Growth Disorders - blood
Growth Disorders - diagnosis
Growth Disorders - physiopathology
Growth Hormone - blood
Growth Hormone - deficiency
Humans
Hydrocortisone - blood
Hypoglycemia - blood
Hypoglycemic Agents
Insulin
Male
Medical sciences
Peptide Hormones - blood
Time Factors
Vertebrates: endocrinology
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Summary:Summary Objective  Ghrelin activates the growth hormone secretagogue receptor GHS‐R. It strongly stimulates GH secretion and has a role in energy homeostasis. The relationship between plasma ghrelin and cortisol levels during insulin‐induced hypoglycaemia in prepubertal and pubertal children has not yet been investigated. The aim of the present study was to establish whether insulin‐induced hypoglycaemia stimulates ghrelin secretion and whether changes in ghrelin concentrations are related to changes in GH and cortisol in children. Design and patients  We studied a group of 20 children and adolescents (five girls, 15 boys, mean age 10·8 ± 3·7 years) undergoing insulin tolerance tests (ITTs) for clinical investigation of GH deficiency. Measurements  Stimulation tests were performed to investigate the relationship between ghrelin, GH, cortisol and glucose levels according to age and pubertal stage by determining the ghrelin profiles during insulin‐induced hypoglycaemia (at 0, 60 and 120 min). Results  Ghrelin was significantly and inversely related to body weight, height, body mass index (BMI) and age of children (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2006.02701.x