Review article: increasing the dose of oral mesalazine therapy for active ulcerative colitis does not improve remission rates

• Published in: Alimentary pharmacology & therapeutics 2007-11, Vol.26 (9), p.1179-1186
• Main Authors: SAFDI, A. V., COHEN, R. D.
• Format: Article
• Language: English
• Subjects: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Biological and medical sciences; Colitis, Ulcerative - drug therapy; Delayed-Action Preparations - administration & dosage; Digestive system; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Medical sciences; Mesalamine - administration & dosage; Other diseases. Semiology; Pharmacology. Drug treatments; Remission Induction - methods; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Treatment Outcome
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/j.1365-2036.2007.03471.x

Summary Background  Oral mesalazine (mesalamine, 5‐aminosalicylic acid) formulations are effective in the treatment of active ulcerative colitis. All formulations contain the same active drug but differ with regard to mechanisms to deliver the drug to the colon. Patients who fail to respond to initial therapy are often administered higher doses of the same formulation. Aim  To review published trials of oral mesalazine formulations in treating active ulcerative colitis and to examine the effect of dose escalation on remission rates. Results  Increasing the doses of oral mesalazine formulations does not result in higher remission rates, although increasing the doses of some formulations has been effective in increasing symptomatic improvement and/or response to treatment. Conclusions  Because oral mesalazine formulations do not demonstrate a significant dose response with regard to induction of remission of active ulcerative colitis, simple dose escalation may not be the most effective course for patients who fail to respond to initial mesalazine treatment.